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Optics Letters

Optics Letters


  • Editor: Alan E. Willner
  • Vol. 38, Iss. 13 — Jul. 1, 2013
  • pp: 2324–2326

Compression of Born ratio for fluorescence molecular tomography/x-ray computed tomography hybrid imaging: methodology and in vivo validation

Pouyan Mohajerani and Vasilis Ntziachristos  »View Author Affiliations

Optics Letters, Vol. 38, Issue 13, pp. 2324-2326 (2013)

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The 360° rotation geometry of the hybrid fluorescence molecular tomography/x-ray computed tomography modality allows for acquisition of very large datasets, which pose numerical limitations on the reconstruction. We propose a compression method that takes advantage of the correlation of the Born-normalized signal among sources in spatially formed clusters to reduce the size of system model. The proposed method has been validated using an ex vivo study and an in vivo study of a nude mouse with a subcutaneous 4T1 tumor, with and without inclusion of a priori anatomical information. Compression rates of up to two orders of magnitude with minimum distortion of reconstruction have been demonstrated, resulting in large reduction in weight matrix size and reconstruction time.

© 2013 Optical Society of America

OCIS Codes
(100.6950) Image processing : Tomographic image processing
(170.6960) Medical optics and biotechnology : Tomography
(110.0113) Imaging systems : Imaging through turbid media
(110.6955) Imaging systems : Tomographic imaging

ToC Category:
Imaging Systems

Original Manuscript: April 9, 2013
Manuscript Accepted: May 30, 2013
Published: June 26, 2013

Virtual Issues
Vol. 8, Iss. 8 Virtual Journal for Biomedical Optics

Pouyan Mohajerani and Vasilis Ntziachristos, "Compression of Born ratio for fluorescence molecular tomography/x-ray computed tomography hybrid imaging: methodology and in vivo validation," Opt. Lett. 38, 2324-2326 (2013)

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