OSA's Digital Library

Optics Letters

Optics Letters


  • Editor: Alan E. Willner
  • Vol. 38, Iss. 14 — Jul. 15, 2013
  • pp: 2407–2409

Regularization functional semi-automated incorporation of anatomical prior information in image-guided fluorescence tomography

Robert W. Holt, Scott Davis, and Brian W. Pogue  »View Author Affiliations

Optics Letters, Vol. 38, Issue 14, pp. 2407-2409 (2013)

View Full Text Article

Enhanced HTML    Acrobat PDF (341 KB)

Browse Journals / Lookup Meetings

Browse by Journal and Year


Lookup Conference Papers

Close Browse Journals / Lookup Meetings

Article Tools



The use of anatomical priors in fluorescence tomography is known to improve image quality and accuracy significantly. However, the use of prior information is often implemented by incorporating user segmented structural images into the optical reconstruction algorithm, a process requiring significant time and expertise. We propose an automated implementation which encodes the gray-scale prior image directly into the regularization term, eliminating the need for direct prior image segmentation, which is extendable to any spatially defined prior data. The proposed method is supported by in vivo studies.

© 2013 Optical Society of America

OCIS Codes
(170.3010) Medical optics and biotechnology : Image reconstruction techniques
(170.6960) Medical optics and biotechnology : Tomography

ToC Category:
Medical Optics and Biotechnology

Original Manuscript: May 1, 2013
Revised Manuscript: June 10, 2013
Manuscript Accepted: June 10, 2013
Published: July 5, 2013

Virtual Issues
Vol. 8, Iss. 8 Virtual Journal for Biomedical Optics

Robert W. Holt, Scott Davis, and Brian W. Pogue, "Regularization functional semi-automated incorporation of anatomical prior information in image-guided fluorescence tomography," Opt. Lett. 38, 2407-2409 (2013)

Sort:  Author  |  Year  |  Journal  |  Reset  


  1. S. H. Katamreddy and P. K. Yalavarthy, J. Opt. Soc. Am. A 29, 649 (2012). [CrossRef]
  2. A. Ale, R. B. Schulz, A. Sarantopoulos, and V. Ntziachristos, Med. Phys. 37, 1976 (2010). [CrossRef]
  3. T. Correia, J. Aguirre, A. Sisniega, J. Chamorro-Servent, J. Abascal, J. J. Vaquero, M. Desco, V. Kolehmainen, and S. Arridge, Biomed. Opt. Express 2, 2632 (2011). [CrossRef]
  4. S. C. Davis, H. Dehghani, J. Wang, S. Jiang, B. W. Pogue, and K. D. Paulsen, Opt. Express 15, 4066 (2007). [CrossRef]
  5. C. Panagiotou, S. Somayajula, A. P. Gibson, M. Schweiger, R. M. Leahy, and S. R. Arridge, J. Opt. Soc. Am. A 26, 1277 (2009). [CrossRef]
  6. B. Brooksby, S. Jiang, H. Dehghani, B. W. Pogue, K. D. Paulsen, J. Weaver, C. Kogel, and S. P. Poplack, J. Biomed. Opt. 10, 051504 (2005). [CrossRef]
  7. Q. Fang, R. H. Moore, D. B. Kopans, and D. A. Boas, Biomed. Opt. Express 1, 223 (2010). [CrossRef]
  8. M. Jermyn, B. Pogue, H. R. Ghadyani, S. Davis, M. A. Mastanduno, and H. Dehghani, A User-Enabling Visual Workflow for Near-Infrared Light Transport Modeling in Tissue (Optical Society of America, 2012), paper BW1A.7.
  9. S. C. Davis, K. S. Samkoe, J. A. O’Hara, S. L. Gibbs-Strauss, H. L. Payne, P. J. Hoopes, K. D. Paulsen, and B. W. Pogue, Acad. Radiol. 17, 271 (2010). [CrossRef]
  10. S. C. Davis, K. S. Samkoe, J. A. O’Hara, S. L. Gibbs-Strauss, K. D. Paulsen, and B. W. Pogue, J. Biomed. Opt. 15, 051602 (2010). [CrossRef]

Cited By

Alert me when this paper is cited

OSA is able to provide readers links to articles that cite this paper by participating in CrossRef's Cited-By Linking service. CrossRef includes content from more than 3000 publishers and societies. In addition to listing OSA journal articles that cite this paper, citing articles from other participating publishers will also be listed.


Fig. 1. Fig. 2. Fig. 3.

« Previous Article  |  Next Article »

OSA is a member of CrossRef.

CrossCheck Deposited