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Optics Letters

| RAPID, SHORT PUBLICATIONS ON THE LATEST IN OPTICAL DISCOVERIES

  • Editor: Alan E. Willner
  • Vol. 38, Iss. 14 — Jul. 15, 2013
  • pp: 2572–2574

Imaging the electro-kinetic response of biological tissues with optical coherence tomography

K. Wawrzyn, V. Demidov, B. Vuong, M. K. Harduar, C. Sun, V. X. D. Yang, O. Doganay, V. Toronov, and Y. Xu  »View Author Affiliations


Optics Letters, Vol. 38, Issue 14, pp. 2572-2574 (2013)
http://dx.doi.org/10.1364/OL.38.002572


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Abstract

We demonstrate the feasibility of using optical coherence tomography (OCT) to detect and image an electro-kinetic response: electric-field induced optical changes (EIOC) in soft biological tissues. A low-frequency electric field was applied to ex vivo samples of porcine heart tissues, while OCT signals were acquired continuously. Experimental results show that the amplitude of the OCT signal change is proportional to the amplitude and inversely proportional to the frequency of the applied electric field. We show that the nonconductive component of the sample was eliminated in the normalized EIOC image. To the best our knowledge, this is the first time a two-dimensional image related to the electro-kinetic response of soft tissues is obtained with depth resolution. Since electro-kinetic properties can change during cancerogenesis, EIOC imaging can potentially be used for cancer detection.

© 2013 Optical Society of America

OCIS Codes
(110.4500) Imaging systems : Optical coherence tomography
(170.7180) Medical optics and biotechnology : Ultrasound diagnostics
(170.2655) Medical optics and biotechnology : Functional monitoring and imaging
(170.6935) Medical optics and biotechnology : Tissue characterization

ToC Category:
Spectroscopy

History
Original Manuscript: April 22, 2013
Revised Manuscript: June 6, 2013
Manuscript Accepted: June 10, 2013
Published: July 12, 2013

Virtual Issues
Vol. 8, Iss. 8 Virtual Journal for Biomedical Optics

Citation
K. Wawrzyn, V. Demidov, B. Vuong, M. K. Harduar, C. Sun, V. X. D. Yang, O. Doganay, V. Toronov, and Y. Xu, "Imaging the electro-kinetic response of biological tissues with optical coherence tomography," Opt. Lett. 38, 2572-2574 (2013)
http://www.opticsinfobase.org/ol/abstract.cfm?URI=ol-38-14-2572


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