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Optics Letters

| RAPID, SHORT PUBLICATIONS ON THE LATEST IN OPTICAL DISCOVERIES

  • Editor: Alan E. Willner
  • Vol. 38, Iss. 16 — Aug. 15, 2013
  • pp: 3017–3020

Continuous wide-field characterization of drug release from skin substitute using off-axis interferometry

Haniel Gabai, Maya Baranes-Zeevi, Meital Zilberman, and Natan T. Shaked  »View Author Affiliations


Optics Letters, Vol. 38, Issue 16, pp. 3017-3020 (2013)
http://dx.doi.org/10.1364/OL.38.003017


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Abstract

We achieved continuous, noncontact wide-field imaging and characterization of drug release from a polymeric device in vitro by uniquely using off-axis interferometric imaging. Unlike the current gold-standard methods in this field, which are usually based on chromatography and spectroscopy, our method requires no user intervention during the experiment and involves less lab consumable instruments. Using a simplified interferometric imaging system, we experimentally demonstrate the characterization of anesthetic drug release (Bupivacaine) from a soy-based protein matrix, which is used as a skin substitute for wound dressing. Our results demonstrate the potential of interferometric imaging as an inexpensive and easy-to-use alternative for characterization of drug release in vitro.

© 2013 Optical Society of America

OCIS Codes
(090.0090) Holography : Holography
(120.3180) Instrumentation, measurement, and metrology : Interferometry
(120.4630) Instrumentation, measurement, and metrology : Optical inspection
(120.4640) Instrumentation, measurement, and metrology : Optical instruments
(160.5470) Materials : Polymers
(160.1435) Materials : Biomaterials

ToC Category:
Instrumentation, Measurement, and Metrology

History
Original Manuscript: June 5, 2013
Revised Manuscript: July 9, 2013
Manuscript Accepted: July 15, 2013
Published: August 7, 2013

Virtual Issues
Vol. 8, Iss. 9 Virtual Journal for Biomedical Optics

Citation
Haniel Gabai, Maya Baranes-Zeevi, Meital Zilberman, and Natan T. Shaked, "Continuous wide-field characterization of drug release from skin substitute using off-axis interferometry," Opt. Lett. 38, 3017-3020 (2013)
http://www.opticsinfobase.org/ol/abstract.cfm?URI=ol-38-16-3017


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