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Optics Letters

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  • Editor: Alan E. Willner
  • Vol. 38, Iss. 19 — Oct. 1, 2013
  • pp: 3882–3885

Calibration-free in vivo transverse blood flowmetry based on cross correlation of slow time profiles from photoacoustic microscopy

Yong Zhou, Jinyang Liang, Konstantin I. Maslov, and Lihong V. Wang  »View Author Affiliations


Optics Letters, Vol. 38, Issue 19, pp. 3882-3885 (2013)
http://dx.doi.org/10.1364/OL.38.003882


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Abstract

We propose a cross-correlation-based method to measure blood-flow velocity by using photoacoustic microscopy. Unlike in previous autocorrelation-based methods, the measured flow velocity here is independent of particle size. Thus an absolute flow velocity can be obtained without calibration. We first measured the flow velocity ex vivo, using defibrinated bovine blood. Then flow velocities in vessels with different structures in a mouse ear were quantified in vivo. We further measured the flow variation in the same vessel and at a vessel bifurcation. All the experimental results indicate that our method can be used to accurately quantify blood velocity in vivo.

© 2013 Optical Society of America

OCIS Codes
(120.7250) Instrumentation, measurement, and metrology : Velocimetry
(170.5120) Medical optics and biotechnology : Photoacoustic imaging
(170.2655) Medical optics and biotechnology : Functional monitoring and imaging

ToC Category:
Medical Optics and Biotechnology

History
Original Manuscript: July 30, 2013
Manuscript Accepted: August 26, 2013
Published: September 26, 2013

Citation
Yong Zhou, Jinyang Liang, Konstantin I. Maslov, and Lihong V. Wang, "Calibration-free in vivo transverse blood flowmetry based on cross correlation of slow time profiles from photoacoustic microscopy," Opt. Lett. 38, 3882-3885 (2013)
http://www.opticsinfobase.org/ol/abstract.cfm?URI=ol-38-19-3882

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