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Optics Letters

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  • Editor: Alan E. Willner
  • Vol. 38, Iss. 20 — Oct. 15, 2013
  • pp: 4170–4173

Nanodiamonds with silicon vacancy defects for nontoxic photostable fluorescent labeling of neural precursor cells

Tobias D. Merson, Stefania Castelletto, Igor Aharonovich, Alisa Turbic, Trevor J. Kilpatrick, and Ann M. Turnley  »View Author Affiliations


Optics Letters, Vol. 38, Issue 20, pp. 4170-4173 (2013)
http://dx.doi.org/10.1364/OL.38.004170


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Abstract

Nanodiamonds (NDs) containing silicon vacancy (SiV) defects were evaluated as a potential biomarker for the labeling and fluorescent imaging of neural precursor cells (NPCs). SiV-containing NDs were synthesized using chemical vapor deposition and silicon ion implantation. Spectrally, SiV-containing NDs exhibited extremely stable fluorescence and narrow bandwidth emission with an excellent signal to noise ratio exceeding that of NDs containing nitrogen-vacancy centers. NPCs labeled with NDs exhibited normal cell viability and proliferative properties consistent with biocompatibility. We conclude that SiV-containing NDs are a promising biomedical research tool for cellular labeling and optical imaging in stem cell research.

© 2013 Optical Society of America

OCIS Codes
(160.2540) Materials : Fluorescent and luminescent materials
(170.1530) Medical optics and biotechnology : Cell analysis
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(260.1180) Physical optics : Crystal optics
(160.4236) Materials : Nanomaterials

ToC Category:
Medical Optics and Biotechnology

History
Original Manuscript: August 2, 2013
Manuscript Accepted: September 8, 2013
Published: October 11, 2013

Citation
Tobias D. Merson, Stefania Castelletto, Igor Aharonovich, Alisa Turbic, Trevor J. Kilpatrick, and Ann M. Turnley, "Nanodiamonds with silicon vacancy defects for nontoxic photostable fluorescent labeling of neural precursor cells," Opt. Lett. 38, 4170-4173 (2013)
http://www.opticsinfobase.org/ol/abstract.cfm?URI=ol-38-20-4170


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