OSA's Digital Library

Optics Letters

Optics Letters

| RAPID, SHORT PUBLICATIONS ON THE LATEST IN OPTICAL DISCOVERIES

  • Editor: Alan E. Willner
  • Vol. 38, Iss. 22 — Nov. 15, 2013
  • pp: 4526–4529

En face optical coherence tomography of transient light response at photoreceptor outer segments in living frog eyecup

Benquan Wang, Rongwen Lu, Qiuxiang Zhang, Yuqiang Jiang, and Xincheng Yao  »View Author Affiliations


Optics Letters, Vol. 38, Issue 22, pp. 4526-4529 (2013)
http://dx.doi.org/10.1364/OL.38.004526


View Full Text Article

Enhanced HTML    Acrobat PDF (638 KB)





Browse Journals / Lookup Meetings

Browse by Journal and Year


   


Lookup Conference Papers

Close Browse Journals / Lookup Meetings

Article Tools

Share
Citations

Abstract

This study was designed to test the feasibility of en face mapping of the transient intrinsic optical signal (IOS) response at photoreceptor outer segments and to assess the effect of spatial resolution on functional IOS imaging of retinal photoreceptors. A line-scan optical coherence tomography (LS-OCT) was constructed to achieve depth-resolved functional IOS imaging of living frog eyecups. Rapid en face OCT revealed transient IOS almost immediately (<3ms) after the onset of visible light flashes at photoreceptor outer segments. Quantitative analysis indicated that the IOS kinetics may reflect dynamics of G-protein binding and releasing in early phases of visual transduction, and high resolution is essential to differentiate positive and negative IOS changes in adjacent locations.

© 2013 Optical Society of America

OCIS Codes
(170.0110) Medical optics and biotechnology : Imaging systems
(170.2655) Medical optics and biotechnology : Functional monitoring and imaging
(170.5755) Medical optics and biotechnology : Retina scanning

ToC Category:
Medical Optics and Biotechnology

History
Original Manuscript: August 22, 2013
Manuscript Accepted: September 30, 2013
Published: November 4, 2013

Virtual Issues
Vol. 9, Iss. 1 Virtual Journal for Biomedical Optics

Citation
Benquan Wang, Rongwen Lu, Qiuxiang Zhang, Yuqiang Jiang, and Xincheng Yao, "En face optical coherence tomography of transient light response at photoreceptor outer segments in living frog eyecup," Opt. Lett. 38, 4526-4529 (2013)
http://www.opticsinfobase.org/ol/abstract.cfm?URI=ol-38-22-4526


Sort:  Author  |  Year  |  Journal  |  Reset  

References

  1. C. A. Curcio, N. E. Medeiros, and C. L. Millican, Investig. Ophthalmol. Vis. Sci. 37, 1236 (1996).
  2. D. Nagy, B. Schonfisch, E. Zrenner, and H. Jagle, Investig. Ophthalmol. Vis. Sci. 49, 4664 (2008). [CrossRef]
  3. J. S. Sunness, R. W. Massof, M. A. Johnson, N. M. Bressler, S. B. Bressler, and S. L. Fine, Ophthalmology 96, 375 (1989).
  4. H. P. Scholl and E. Zrenner, Surv. Ophthalmol. 45, 29 (2000). [CrossRef]
  5. D. C. Hood, Prog. Retinal Eye Res. 19, 607 (2000). [CrossRef]
  6. H. A. Quigley, E. M. Addicks, and W. R. Green, Arch. Ophthalmol. 100, 135 (1982). [CrossRef]
  7. S. G. Jacobson, A. V. Cideciyan, A. Iannaccone, R. G. Weleber, G. A. Fishman, A. M. Maguire, L. M. Affatigato, J. Bennett, E. A. Pierce, M. Danciger, D. B. Farber, and E. M. Stone, Investig. Ophthalmol. Vis. Sci. 41, 1898 (2000).
  8. P. T. Johnson, G. P. Lewis, K. C. Talaga, M. N. Brown, P. J. Kappel, S. K. Fisher, D. H. Anderson, and L. V. Johnson, Investig. Ophthalmol. Vis. Sci. 44, 4481 (2003). [CrossRef]
  9. R. E. Hogg and U. Chakravarthy, Prog. Retinal Eye Res. 25, 249 (2006). [CrossRef]
  10. J. L. Schei, M. D. McCluskey, A. J. Foust, X. C. Yao, and D. M. Rector, Neuroimage 40, 1034 (2008). [CrossRef]
  11. X. C. Yao, A. Foust, D. M. Rector, B. Barrowes, and J. S. George, Biophys. J. 88, 4170 (2005). [CrossRef]
  12. X. C. Yao, D. M. Rector, and J. S. George, Appl. Opt. 42, 2972 (2003). [CrossRef]
  13. R. W. Lu, Q. X. Zhang, and X. C. Yao, Opt. Lett. 36, 1866 (2011). [CrossRef]
  14. X. C. Yao, W. X. Cui, Y. C. Li, W. Zhang, R. W. Lu, A. Thompson, F. Amthor, and X. J. Wang, J. Mod. Opt. 59, 843 (2012). [CrossRef]
  15. Y. C. Li, W. X. Cui, X. J. Wang, F. Amthor, R. W. Lu, A. Thompson, and X. C. Yao, Opt. Express 19, 99 (2011). [CrossRef]
  16. J. Schallek, H. Li, R. Kardon, Y. Kwon, M. Abramoff, P. Soliz, and D. Ts’o, Investig. Ophthalmol. Vis. Sci. 50, 4865 (2009). [CrossRef]
  17. G. Hanazono, K. Tsunoda, K. Shinoda, K. Tsubota, Y. Miyake, and M. Tanifuji, Investig. Ophthalmol. Vis. Sci. 48, 2903 (2007). [CrossRef]
  18. R. S. Jonnal, J. Rha, Y. Zhang, B. Cense, W. H. Gao, and D. T. Miller, Opt. Express 15, 16141 (2007). [CrossRef]
  19. K. Grieve and A. Roorda, Investig. Ophthalmol. Vis. Sci. 49, 713 (2008). [CrossRef]
  20. J. Rha, B. Schroeder, P. Godara, and J. Carroll, Opt. Lett. 34, 3782 (2009). [CrossRef]
  21. X. C. Yao, A. Yamauchi, B. Perry, and J. S. George, Appl. Opt. 44, 2019 (2005). [CrossRef]
  22. V. J. Srinivasan, M. Wojtkowski, J. G. Fujimoto, and J. S. Duker, Opt. Lett. 31, 2308 (2006). [CrossRef]
  23. K. Bizheva, R. Pflug, B. Hermann, B. Povazay, H. Sattmann, P. Qiu, E. Anger, H. Reitsamer, S. Popov, J. R. Taylor, A. Unterhuber, P. Ahnelt, and W. Drexler, Proc. Natl. Acad. Sci. U.S.A. 103, 5066 (2006). [CrossRef]
  24. Q. X. Zhang, R. W. Lu, C. A. Curcio, and X. C. Yao, Investig. Ophthalmol. Vis. Sci. 53, 8139 (2012). [CrossRef]
  25. Q. X. Zhang, R. W. Lu, Y. G. Li, and X. C. Yao, Opt. Lett. 36, 4692 (2011). [CrossRef]
  26. R. W. Lu, C. A. Curcio, Y. Zhang, Q. X. Zhang, S. J. Pittler, D. Deretic, and X. C. Yao, J. Biomed. Opt. 17, 060504 (2012). [CrossRef]
  27. K. P. Hofmann, R. Uhl, W. Hoffmann, and W. Kreutz, Biophys. Struct. Mech. 2, 61 (1976). [CrossRef]
  28. H. Kuhn, N. Bennett, M. Michel-Villaz, and M. Chabre, Proc. Natl. Acad. Sci. USA 78, 6873 (1981). [CrossRef]
  29. V. Y. Arshavsky, T. D. Lamb, and E. N. Pugh, Annu. Rev. Physiol. 64, 153 (2002). [CrossRef]

Cited By

Alert me when this paper is cited

OSA is able to provide readers links to articles that cite this paper by participating in CrossRef's Cited-By Linking service. CrossRef includes content from more than 3000 publishers and societies. In addition to listing OSA journal articles that cite this paper, citing articles from other participating publishers will also be listed.

Figures

Fig. 1. Fig. 2. Fig. 3.
 
Fig. 4.
 

« Previous Article  |  Next Article »

OSA is a member of CrossRef.

CrossCheck Deposited