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Optics Letters

Optics Letters


  • Editor: Alan E. Willner
  • Vol. 38, Iss. 22 — Nov. 15, 2013
  • pp: 4530–4533

In vivo x-ray luminescence tomographic imaging with single-view data

Xin Liu, Qimei Liao, and Hongkai Wang  »View Author Affiliations

Optics Letters, Vol. 38, Issue 22, pp. 4530-4533 (2013)

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X-ray luminescence computed tomography (XLCT) is a new molecular imaging modality. In this Letter, we first in vivo tomographically image the near-IR-emitting nanophosphor (Gd2O3:Eu3+) in nude mice (N=2). In practically, incorporating the compressive sensing technique, the XLCT reconstruction is performed only using single-view data. The experimental results indicate that the single-view reconstruction is feasible to image XLCT in vivo. The location error is less than 1.5 mm. Further, the imaging time can be greatly reduced compared with previous XLCT systems. Therefore, it is suited for imaging fast distribution of x-ray-excitable nanophosphors within a biological object.

© 2013 Optical Society of America

OCIS Codes
(110.7440) Imaging systems : X-ray imaging
(170.3010) Medical optics and biotechnology : Image reconstruction techniques
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.6280) Medical optics and biotechnology : Spectroscopy, fluorescence and luminescence
(170.6960) Medical optics and biotechnology : Tomography

ToC Category:
Medical Optics and Biotechnology

Original Manuscript: September 3, 2013
Manuscript Accepted: September 24, 2013
Published: November 4, 2013

Virtual Issues
Vol. 9, Iss. 1 Virtual Journal for Biomedical Optics

Xin Liu, Qimei Liao, and Hongkai Wang, "In vivo x-ray luminescence tomographic imaging with single-view data," Opt. Lett. 38, 4530-4533 (2013)

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