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Optics Letters

Optics Letters


  • Editor: Alan E. Willner
  • Vol. 38, Iss. 22 — Nov. 15, 2013
  • pp: 4605–4608

A sensitive x-ray phase contrast technique for rapid imaging using a single phase grid analyzer

Kaye S. Morgan, Peter Modregger, Sarah C. Irvine, Simon Rutishauser, Vitaliy A. Guzenko, Marco Stampanoni, and Christian David  »View Author Affiliations

Optics Letters, Vol. 38, Issue 22, pp. 4605-4608 (2013)

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Phase contrast x-ray imaging (PCXI) is a promising imaging modality, capable of sensitively differentiating soft tissue structures at high spatial resolution. However, high sensitivity often comes at the cost of a long exposure time or multiple exposures per image, limiting the imaging speed and possibly increasing the radiation dose. Here, we demonstrate a PCXI method that uses a single short exposure to sensitively capture sample phase information, permitting high speed x-ray movies and live animal imaging. The method illuminates a checkerboard phase grid to produce a fine grid-like intensity reference pattern at the detector, then spatially maps sample-induced distortions of this pattern to recover differential phase images of the sample. The use of a phase grid is an improvement on our previous absorption grid work in two ways. There is minimal loss in x-ray flux, permitting faster imaging, and, a very fine pattern is produced for homogenous high spatial resolution. We describe how this pattern permits retrieval of five images from a single exposure; the sample phase gradient images in the horizontal and vertical directions, a projected phase depth image, an edge-enhanced image, and a type of scattering image. Finally, we describe how the reconstruction technique can achieve subpixel distortion retrieval and study the behavior of the technique in regard to analysis technique, Talbot distance, and exposure time.

© 2013 Optical Society of America

OCIS Codes
(100.5070) Image processing : Phase retrieval
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(340.6720) X-ray optics : Synchrotron radiation
(340.7440) X-ray optics : X-ray imaging
(350.2770) Other areas of optics : Gratings
(110.3010) Imaging systems : Image reconstruction techniques

ToC Category:
Medical Optics and Biotechnology

Original Manuscript: September 6, 2013
Manuscript Accepted: September 24, 2013
Published: November 6, 2013

Virtual Issues
Vol. 9, Iss. 1 Virtual Journal for Biomedical Optics

Kaye S. Morgan, Peter Modregger, Sarah C. Irvine, Simon Rutishauser, Vitaliy A. Guzenko, Marco Stampanoni, and Christian David, "A sensitive x-ray phase contrast technique for rapid imaging using a single phase grid analyzer," Opt. Lett. 38, 4605-4608 (2013)

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