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Optics Letters

Optics Letters


  • Editor: Alan E. Willner
  • Vol. 38, Iss. 6 — Mar. 15, 2013
  • pp: 992–994

Thermal and optical characterization of micro-LED probes for in vivo optogenetic neural stimulation

Niall McAlinden, David Massoubre, Elliot Richardson, Erdan Gu, Shuzo Sakata, Martin D. Dawson, and Keith Mathieson  »View Author Affiliations

Optics Letters, Vol. 38, Issue 6, pp. 992-994 (2013)

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Within optogenetics there is a need for compact light sources that are capable of delivering light with excellent spatial, temporal, and spectral resolution to deep brain structures. Here, we demonstrate a custom GaN-based LED probe for such applications and the electrical, optical, and thermal properties are analyzed. The output power density and emission spectrum were found to be suitable for stimulating channelrhodopsin-2, one of the most common light-sensitive proteins currently used in optogenetics. The LED device produced high light intensities, far in excess of those required to stimulate the light-sensitive proteins within the neurons. Thermal performance was also investigated, illustrating that a broad range of operating regimes in pulsed mode are accessible while keeping a minimum increase in temperature for the brain (0.5°C). This type of custom device represents a significant step forward for the optogenetics community, allowing multiple bright excitation sites along the length of a minimally invasive neural probe.

© 2013 Optical Society of America

OCIS Codes
(130.3120) Integrated optics : Integrated optics devices
(170.0170) Medical optics and biotechnology : Medical optics and biotechnology
(230.3670) Optical devices : Light-emitting diodes
(170.2945) Medical optics and biotechnology : Illumination design

ToC Category:
Medical Optics and Biotechnology

Original Manuscript: December 6, 2012
Revised Manuscript: February 6, 2013
Manuscript Accepted: February 10, 2013
Published: March 15, 2013

Virtual Issues
Vol. 8, Iss. 4 Virtual Journal for Biomedical Optics

Niall McAlinden, David Massoubre, Elliot Richardson, Erdan Gu, Shuzo Sakata, Martin D. Dawson, and Keith Mathieson, "Thermal and optical characterization of micro-LED probes for in vivo optogenetic neural stimulation," Opt. Lett. 38, 992-994 (2013)

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