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Thermal and optical characterization of micro-LED probes for in vivo optogenetic neural stimulation |
Optics Letters, Vol. 38, Issue 6, pp. 992-994 (2013)
http://dx.doi.org/10.1364/OL.38.000992
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Abstract
Within optogenetics there is a need for compact light sources that are capable of delivering light with excellent spatial, temporal, and spectral resolution to deep brain structures. Here, we demonstrate a custom GaN-based LED probe for such applications and the electrical, optical, and thermal properties are analyzed. The output power density and emission spectrum were found to be suitable for stimulating channelrhodopsin-2, one of the most common light-sensitive proteins currently used in optogenetics. The LED device produced high light intensities, far in excess of those required to stimulate the light-sensitive proteins within the neurons. Thermal performance was also investigated, illustrating that a broad range of operating regimes in pulsed mode are accessible while keeping a minimum increase in temperature for the brain (0.5°C). This type of custom device represents a significant step forward for the optogenetics community, allowing multiple bright excitation sites along the length of a minimally invasive neural probe.
© 2013 Optical Society of America
OCIS Codes
(130.3120) Integrated optics : Integrated optics devices
(170.0170) Medical optics and biotechnology : Medical optics and biotechnology
(230.3670) Optical devices : Light-emitting diodes
(170.2945) Medical optics and biotechnology : Illumination design
ToC Category:
Medical Optics and Biotechnology
History
Original Manuscript: December 6, 2012
Revised Manuscript: February 6, 2013
Manuscript Accepted: February 10, 2013
Published: March 15, 2013
Citation
Niall McAlinden, David Massoubre, Elliot Richardson, Erdan Gu, Shuzo Sakata, Martin D. Dawson, and Keith Mathieson, "Thermal and optical characterization of micro-LED probes for in vivo optogenetic neural stimulation," Opt. Lett. 38, 992-994 (2013)
http://www.opticsinfobase.org/ol/abstract.cfm?URI=ol-38-6-992
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