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Optics Letters

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  • Editor: Alan E. Willner
  • Vol. 38, Iss. 8 — Apr. 15, 2013
  • pp: 1319–1321

High-precision microscopic phase imaging without phase unwrapping for cancer cell identification

Eriko Watanabe, Takashi Hoshiba, and Bahram Javidi  »View Author Affiliations


Optics Letters, Vol. 38, Issue 8, pp. 1319-1321 (2013)
http://dx.doi.org/10.1364/OL.38.001319


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Abstract

Experiments for cell identification are presented using a high-precision cell phase measurement system that does not require any phase unwrapping. This system is based on a Mach–Zehnder interferometer using a phase-locking technique, and it measures the change in optical path length while the sample is scanned across the optical axis. The spatial resolution is estimated to be less than 1.1 μm. The sensitivity of optical path length difference is estimated to be less than 2 nm. Using experiments, we investigate the potential of this approach for cancer cell identification. In our preliminary experiments, cancer cells were distinguished from normal cells through comparison of optical path length differences.

© 2013 Optical Society of America

OCIS Codes
(120.5050) Instrumentation, measurement, and metrology : Phase measurement
(170.4580) Medical optics and biotechnology : Optical diagnostics for medicine
(180.3170) Microscopy : Interference microscopy
(110.5086) Imaging systems : Phase unwrapping

ToC Category:
Microscopy

History
Original Manuscript: October 22, 2012
Revised Manuscript: January 24, 2013
Manuscript Accepted: January 30, 2013
Published: April 12, 2013

Virtual Issues
Vol. 8, Iss. 5 Virtual Journal for Biomedical Optics

Citation
Eriko Watanabe, Takashi Hoshiba, and Bahram Javidi, "High-precision microscopic phase imaging without phase unwrapping for cancer cell identification," Opt. Lett. 38, 1319-1321 (2013)
http://www.opticsinfobase.org/ol/abstract.cfm?URI=ol-38-8-1319


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