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Optics Letters

Optics Letters


  • Editor: Alan E. Willner
  • Vol. 38, Iss. 9 — May. 1, 2013
  • pp: 1401–1403

Deep tissue flowmetry based on diffuse speckle contrast analysis

Renzhe Bi, Jing Dong, and Kijoon Lee  »View Author Affiliations

Optics Letters, Vol. 38, Issue 9, pp. 1401-1403 (2013)

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Diffuse correlation spectroscopy (DCS) is an emerging modality for noninvasive deep tissue blood flow monitoring that is becoming increasingly popular; it conducts an autocorrelation analysis of fast fluctuating photon count signals from a single speckle. In this Letter, we show that the same level of deep tissue flow information can be obtained from a much simpler analysis on the spatial distribution of the speckles that is obtained by a CCD camera, which we named diffuse speckle contrast analysis (DSCA). Both the flow phantom experiment and in vivo cuff occlusion data are presented. DSCA can be considered a new optical modality that combines DCS and laser speckle contrast imaging (LSCI), which exploits simple instrumentation and analysis and yet is sensitive to deep tissue flow.

© 2013 Optical Society of America

OCIS Codes
(030.6140) Coherence and statistical optics : Speckle
(170.6480) Medical optics and biotechnology : Spectroscopy, speckle
(290.1990) Scattering : Diffusion

ToC Category:
Medical Optics and Biotechnology

Original Manuscript: September 28, 2012
Revised Manuscript: January 9, 2013
Manuscript Accepted: March 18, 2013
Published: April 24, 2013

Virtual Issues
Vol. 8, Iss. 6 Virtual Journal for Biomedical Optics

Renzhe Bi, Jing Dong, and Kijoon Lee, "Deep tissue flowmetry based on diffuse speckle contrast analysis," Opt. Lett. 38, 1401-1403 (2013)

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