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Optics Letters

Optics Letters


  • Editor: Alan E. Willner
  • Vol. 38, Iss. 9 — May. 1, 2013
  • pp: 1524–1526

Use of hyperspectral imaging for label-free decoding and detection of biomarkers

Tongzhou Wang, Qiang Li, Xin Li, Songmin Zhao, Ying Lu, and Guoliang Huang  »View Author Affiliations

Optics Letters, Vol. 38, Issue 9, pp. 1524-1526 (2013)

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Detecting the existence of biomarkers is one of the most important issues in molecular diagnosis. This Letter presents a label-free decoding and detection method for biomarker tests based on hyperspectral imaging and interferometry. The decoding and detection results were extracted from a single hyperspectral image with different spectrum-to-thickness reconstructing algorithms, which made the testing procedure extremely fast and simple. The coding capacity of this method is more than 400, and the detection sensitivity can reach 2ng/mm2 without fluorescent labeling.

© 2013 Optical Society of America

OCIS Codes
(120.3180) Instrumentation, measurement, and metrology : Interferometry
(170.3010) Medical optics and biotechnology : Image reconstruction techniques
(170.4580) Medical optics and biotechnology : Optical diagnostics for medicine
(100.4145) Image processing : Motion, hyperspectral image processing

ToC Category:
Image Processing

Original Manuscript: January 24, 2013
Revised Manuscript: March 27, 2013
Manuscript Accepted: March 27, 2013
Published: April 29, 2013

Virtual Issues
Vol. 8, Iss. 6 Virtual Journal for Biomedical Optics

Tongzhou Wang, Qiang Li, Xin Li, Songmin Zhao, Ying Lu, and Guoliang Huang, "Use of hyperspectral imaging for label-free decoding and detection of biomarkers," Opt. Lett. 38, 1524-1526 (2013)

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