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Optics Letters

| RAPID, SHORT PUBLICATIONS ON THE LATEST IN OPTICAL DISCOVERIES

  • Editor: Xi-Cheng Zhang
  • Vol. 39, Iss. 11 — Jun. 1, 2014
  • pp: 3328–3331

Confocal photoacoustic microscopy using a single multifunctional lens

Lei Xi, Chaolong Song, and Huabei Jiang  »View Author Affiliations


Optics Letters, Vol. 39, Issue 11, pp. 3328-3331 (2014)
http://dx.doi.org/10.1364/OL.39.003328


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Abstract

Photoacoustic microscopy (PAM) has remained one of the fastest developing biomedical imaging modalities in the past decade. The confocal strategy of optical illumination and acoustic detection is a way to boost the sensitivity of PAM. To achieve confocal PAM, current PAM systems utilize separate acoustic and optical converging devices, making the systems bulky and complicated. In this Letter, we demonstrate the use of a single-liquid lens to successfully achieve acoustic and optical confocal configuration for optical-resolution PAM (ORPAM). Using the lens with a numerical aperture of 0.43, we show that the resolution of the ORPAM system is 4.8 μm with a significantly improved sensitivity of acoustic detection. We also apply this compact ORPAM system to in vivo imaging of the vasculature of a rat ear.

© 2014 Optical Society of America

OCIS Codes
(080.3630) Geometric optics : Lenses
(110.0180) Imaging systems : Microscopy
(110.5120) Imaging systems : Photoacoustic imaging

ToC Category:
Medical Optics and Biotechnology

History
Original Manuscript: March 28, 2014
Revised Manuscript: April 7, 2014
Manuscript Accepted: April 26, 2014
Published: May 30, 2014

Citation
Lei Xi, Chaolong Song, and Huabei Jiang, "Confocal photoacoustic microscopy using a single multifunctional lens," Opt. Lett. 39, 3328-3331 (2014)
http://www.opticsinfobase.org/ol/abstract.cfm?URI=ol-39-11-3328


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