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Optics Letters

Optics Letters


  • Editor: Xi-Cheng Zhang
  • Vol. 39, Iss. 13 — Jul. 1, 2014
  • pp: 3814–3817

In vivo optically encoded photoacoustic flowgraphy

Ruiying Zhang, Lidai Wang, Junjie Yao, Cheng-Hung Yeh, and Lihong V. Wang  »View Author Affiliations

Optics Letters, Vol. 39, Issue 13, pp. 3814-3817 (2014)

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We present an optically encoded photoacoustic (PA) flow imaging method based on optical-resolution PA microscopy. An intensity-modulated continuous-wave laser photothermally encodes the flowing medium, and a pulsed laser generates PA waves to image the encoded heat pattern. Flow speeds can be calculated by cross correlation. The method was validated in phantoms at flow speeds ranging from 0.23 to 11mm/s. Venous blood flow speed in a mouse ear was also measured.

© 2014 Optical Society of America

OCIS Codes
(110.6820) Imaging systems : Thermal imaging
(120.7250) Instrumentation, measurement, and metrology : Velocimetry
(140.6810) Lasers and laser optics : Thermal effects
(170.5120) Medical optics and biotechnology : Photoacoustic imaging

ToC Category:
Imaging Systems

Original Manuscript: March 17, 2014
Manuscript Accepted: April 13, 2014
Published: June 20, 2014

Virtual Issues
Vol. 9, Iss. 9 Virtual Journal for Biomedical Optics

Ruiying Zhang, Lidai Wang, Junjie Yao, Cheng-Hung Yeh, and Lihong V. Wang, "In vivo optically encoded photoacoustic flowgraphy," Opt. Lett. 39, 3814-3817 (2014)

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  1. J. Yao, K. I. Maslov, and L. V. Wang, Technol. Cancer Res. Treat. 11, 301 (2012). [CrossRef]
  2. K. K. Shung, Diagnostic Ultrasound: Imaging and Blood Flow Measurements (CRC, 2005).
  3. A. P. Shepherd and P. Å. Öberg, Laser-Doppler Blood Flowmetry (Springer, 1990), Vol. 107.
  4. Z. Chen, T. E. Milner, S. Srinivas, X. Wang, A. Malekafzali, M. J. C. van Gemert, and J. S. Nelson, Opt. Lett. 22, 1119 (1997). [CrossRef]
  5. L. V. Wang and S. Hu, Science 335, 1458 (2012). [CrossRef]
  6. H. Fang, K. Maslov, and L. V. Wang, Appl. Phys. Lett. 91, 264103 (2007). [CrossRef]
  7. J. Brunker and P. Beard, J. Acoust. Soc. Am. 132, 1780 (2012). [CrossRef]
  8. J. Yao, K. I. Maslov, Y. Shi, L. A. Taber, and L. V. Wang, Opt. Lett. 35, 1419 (2010). [CrossRef]
  9. P. Beard, Int. Focus 1, 602 (2011). [CrossRef]
  10. A. Sheinfeld and A. Eyal, Proc. SPIE 8581, 85811O (2013). [CrossRef]
  11. L. Wang, J. Xia, J. Yao, K. I. Maslov, and L. V. Wang, Phys. Rev. Lett. 111, 204301 (2013). [CrossRef]
  12. L. Wang, J. Yao, K. I. Maslov, W. Xing, and L. V. Wang, J. Biomed. Opt. 18, 117003 (2013).
  13. L. V. Wang and H.-I. Wu, Biomedical Optics: Principles and Imaging (Wiley, 2012).
  14. S. Hu, K. Maslov, and L. V. Wang, Opt. Lett. 36, 1134 (2011). [CrossRef]
  15. C. Yeh, B. Soetikno, S. Hu, K. I. Maslov, and L. V. Wang, Proc. SPIE 8943, 894351 (2014). [CrossRef]
  16. J. Yao, C.-H. Huang, L. Wang, J.-M. Yang, L. Gao, K. I. Maslov, J. Zou, and L. V. Wang, J. Biomed. Opt. 17, 080505 (2012). [CrossRef]

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