OSA's Digital Library

Optics Letters

Optics Letters

| RAPID, SHORT PUBLICATIONS ON THE LATEST IN OPTICAL DISCOVERIES

  • Editor: Xi-Cheng Zhang
  • Vol. 39, Iss. 13 — Jul. 1, 2014
  • pp: 3907–3910

Entropy analysis reveals a simple linear relation between laser speckle and blood flow

Peng Miao, Zhen Chao, Yiguang Zhang, Nan Li, and Nitish V. Thakor  »View Author Affiliations


Optics Letters, Vol. 39, Issue 13, pp. 3907-3910 (2014)
http://dx.doi.org/10.1364/OL.39.003907


View Full Text Article

Enhanced HTML    Acrobat PDF (621 KB)





Browse Journals / Lookup Meetings

Browse by Journal and Year


   


Lookup Conference Papers

Close Browse Journals / Lookup Meetings

Article Tools

Share
Citations

Abstract

Dynamic laser speckles contain motion information of scattering particles which can be estimated by laser speckle contrast analysis (LASCA). In this work, an entropy-based method was proposed to provide a more robust estimation of motion speed. An in vitro flow simulation experiment confirmed a simple linear relation between entropy, exposure time, and speed. A multimodality optical imaging setup is developed to validate the advantages of the entropy method based on laser speckle imaging, green light imaging, and fluorescence imaging. The entropy method overcomes traditional LASCA with less noisy interference, and extracts more visible and detailed vasculatures in vivo. Furthermore, the entropy method provides a more accurate estimation and a stable pattern of blood flow activations in the rat’s somatosensory area under multitrial hand paw stimulations.

© 2014 Optical Society of America

OCIS Codes
(120.6150) Instrumentation, measurement, and metrology : Speckle imaging
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.6480) Medical optics and biotechnology : Spectroscopy, speckle
(170.2655) Medical optics and biotechnology : Functional monitoring and imaging

ToC Category:
Medical Optics and Biotechnology

History
Original Manuscript: April 23, 2014
Revised Manuscript: May 19, 2014
Manuscript Accepted: May 28, 2014
Published: June 25, 2014

Citation
Peng Miao, Zhen Chao, Yiguang Zhang, Nan Li, and Nitish V. Thakor, "Entropy analysis reveals a simple linear relation between laser speckle and blood flow," Opt. Lett. 39, 3907-3910 (2014)
http://www.opticsinfobase.org/ol/abstract.cfm?URI=ol-39-13-3907


Sort:  Author  |  Year  |  Journal  |  Reset  

References

  1. J. D. Briers, Physiol. Meas. 22, R35 (2001). [CrossRef]
  2. M. D. Stern, Nature 254, 56 (1975). [CrossRef]
  3. J. D. Briers and S. Webster, J. Biomed. Opt. 1, 174 (1996). [CrossRef]
  4. A. K. Dunn, B. Hayrunnisa, M. Moskowitz, and D. Boas, J. Cereb. Blood Flow Metabol. 21, 195 (2001). [CrossRef]
  5. A. Rege, K. Murari, A. Seifert, A. P. Pathak, and N. V. Thakor, J. Biomed. Opt. 16, 056006 (2011). [CrossRef]
  6. P. Li, S. Ni, L. Zhang, S. Zeng, and Q. Luo, Opt. Lett. 31, 1824 (2006). [CrossRef]
  7. P. Miao, N. Li, N. V. Thakor, and S. Tong, Opt. Express 18, 218 (2010). [CrossRef]
  8. H. Cheng and T. Q. Duong, Opt. Lett. 32, 2188 (2007). [CrossRef]
  9. D. A. Boas and A. K. Dunn, J. Biomed. Opt. 15, 011109 (2010). [CrossRef]
  10. R. Bandyopadhyay, A. S. Gittings, S. S. Suh, P. K. Dixon, and D. J. Durian, Rev. Sci. Instrum. 76, 093110 (2005). [CrossRef]
  11. R. Bonner and R. Nossal, Appl. Opt. 20, 2097 (1981). [CrossRef]
  12. S. M. S. Kazmi, A. B. Parthasarthy, N. E. Song, T. A. Jones, and A. K. Dunn, J. Cereb. Blood Flow Metabol. 33, 798 (2013). [CrossRef]
  13. T. M. Cover and J. A. Thomas, Elements of Information Theory (Wiley, 2006).
  14. J. A. Bonachela, H. Hinrichsen, and M. A. Munoz, J. Phys. A 41, 202001 (2008). [CrossRef]
  15. P. Grassberger, Phys. Lett. A 128, 369 (1988). [CrossRef]
  16. M. S. Roulston, Physica D 125, 285 (1999). [CrossRef]
  17. T. Schrümann, J. Phys. A 37, L295 (2004). [CrossRef]
  18. K. Murari, N. Li, A. Rege, X. Jia, A. All, and N. V. Thakor, Appl. Opt. 46, 5340 (2007). [CrossRef]
  19. A. Humeau-Heurtier, G. Mahe, S. Durand, and P. Abraham, IEEE Trans. Biomed. Eng. 60, 872 (2013). [CrossRef]

Cited By

Alert me when this paper is cited

OSA is able to provide readers links to articles that cite this paper by participating in CrossRef's Cited-By Linking service. CrossRef includes content from more than 3000 publishers and societies. In addition to listing OSA journal articles that cite this paper, citing articles from other participating publishers will also be listed.

Figures

Fig. 1. Fig. 2. Fig. 3.
 

« Previous Article  |  Next Article »

OSA is a member of CrossRef.

CrossCheck Deposited