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Optics Letters

Optics Letters


  • Editor: Xi-Cheng Zhang
  • Vol. 39, Iss. 13 — Jul. 1, 2014
  • pp: 3911–3914

Ultrawideband reflection-mode optoacoustic mesoscopy

Murad Omar, Dominik Soliman, Jérôme Gateau, and Vasilis Ntziachristos  »View Author Affiliations

Optics Letters, Vol. 39, Issue 13, pp. 3911-3914 (2014)

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We developed a reflection-mode optoacoustic mesoscopy system, based on raster-scanning of a custom designed spherically focused ultrasound detector, enabling seamless epi-illumination of the volume imaged. We study the performance of acoustic-resolution mesoscopy operating at an ultrawideband bandwidth of 20–180 MHz. i.e., a frequency band spreading over virtually an order of magnitude. Using tomographic reconstruction we showcase previously unreported, to our knowledge, axial resolutions of 4 μm and transverse resolutions of 18 μm reaching depths of up to 5 mm. We further investigate the frequency-dependence of features seen on the images to understand the implications of ultrawideband measurements. We show the overall imaging performance and the frequency ranges that contribute to observable resolution improvements from phantoms and animals.

© 2014 Optical Society of America

OCIS Codes
(170.3010) Medical optics and biotechnology : Image reconstruction techniques
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.3890) Medical optics and biotechnology : Medical optics instrumentation
(170.5120) Medical optics and biotechnology : Photoacoustic imaging
(110.5125) Imaging systems : Photoacoustics

ToC Category:
Medical Optics and Biotechnology

Original Manuscript: April 10, 2014
Manuscript Accepted: May 17, 2014
Published: June 25, 2014

Virtual Issues
Vol. 9, Iss. 9 Virtual Journal for Biomedical Optics

Murad Omar, Dominik Soliman, Jérôme Gateau, and Vasilis Ntziachristos, "Ultrawideband reflection-mode optoacoustic mesoscopy," Opt. Lett. 39, 3911-3914 (2014)

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