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Optics Letters

Optics Letters


  • Editor: Xi-Cheng Zhang
  • Vol. 39, Iss. 14 — Jul. 15, 2014
  • pp: 4061–4064

Real-time optoacoustic tomography of indocyanine green perfusion and oxygenation parameters in human finger vasculature

Christian Lutzweiler, Reinhard Meier, Ernst Rummeny, Vasilis Ntziachristos, and Daniel Razansky  »View Author Affiliations

Optics Letters, Vol. 39, Issue 14, pp. 4061-4064 (2014)

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We interrogated whether optoacoustic tomography could be employed to study blood functional parameters and biodistribution of injected fluorescent agents in humans. Using a multichannel scanner at a frame rate of 10 images per second, we obtained cross-sectional images of the human finger in real time, before and after the administration of indocyanine green. We demonstrated that multispectral optoacoustic tomography can sense fast flow kinetics and resolve spatiotemporal characteristics of a common fluorochrome in human vasculature at clinically relevant concentrations. We further register ICG images with oxygen saturation maps and anatomical views of the proximal interphalangeal joint of a healthy volunteer.

© 2014 Optical Society of America

OCIS Codes
(170.1610) Medical optics and biotechnology : Clinical applications
(170.5120) Medical optics and biotechnology : Photoacoustic imaging
(170.5380) Medical optics and biotechnology : Physiology
(170.6920) Medical optics and biotechnology : Time-resolved imaging
(110.6955) Imaging systems : Tomographic imaging

ToC Category:
Medical Optics and Biotechnology

Original Manuscript: March 11, 2014
Revised Manuscript: May 19, 2014
Manuscript Accepted: June 3, 2014
Published: July 2, 2014

Virtual Issues
Vol. 9, Iss. 9 Virtual Journal for Biomedical Optics

Christian Lutzweiler, Reinhard Meier, Ernst Rummeny, Vasilis Ntziachristos, and Daniel Razansky, "Real-time optoacoustic tomography of indocyanine green perfusion and oxygenation parameters in human finger vasculature," Opt. Lett. 39, 4061-4064 (2014)

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