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Optics Letters

Optics Letters


  • Editor: Xi-Cheng Zhang
  • Vol. 39, Iss. 16 — Aug. 15, 2014
  • pp: 4788–4791

Femtosecond pulse shaping enables detection of optical Kerr-effect (OKE) dynamics for molecular imaging

Francisco E. Robles, Martin C. Fischer, and Warren S. Warren  »View Author Affiliations

Optics Letters, Vol. 39, Issue 16, pp. 4788-4791 (2014)

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We apply femtosecond pulse shaping to generate optical pulse trains that directly access a material’s nonlinear refractive index (n2) and can thus determine time-resolved optical Kerr-effect (OKE) dynamics. Two types of static pulse trains are discussed: The first uses two identical fields delayed in time, plus a pump field at a different wavelength. Time-resolved OKE dynamics are retrieved by monitoring the phase of the interference pattern produced by the two identical fields in the Fourier-domain (FD) as a function of pump–probe–time–delay (where the probe is one of the two identical fields). The second pulse train uses three fields with equal time delays, but with the center field phase shifted by π/2. In this pulse scheme, changes on a sample’s nonlinear refractive index produce a new frequency in the FD signal, which in turn yields background-free intensity changes in the conjugate (time) domain and provides superior signal-to-noise ratios. The demonstrated sensitivity improvements enable, for the first time to our knowledge, molecular imaging based on OKE dynamics.

© 2014 Optical Society of America

OCIS Codes
(120.3180) Instrumentation, measurement, and metrology : Interferometry
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(190.3270) Nonlinear optics : Kerr effect
(300.6420) Spectroscopy : Spectroscopy, nonlinear
(180.4315) Microscopy : Nonlinear microscopy

ToC Category:

Original Manuscript: June 5, 2014
Manuscript Accepted: June 27, 2014
Published: August 8, 2014

Virtual Issues
Vol. 9, Iss. 10 Virtual Journal for Biomedical Optics

Francisco E. Robles, Martin C. Fischer, and Warren S. Warren, "Femtosecond pulse shaping enables detection of optical Kerr-effect (OKE) dynamics for molecular imaging," Opt. Lett. 39, 4788-4791 (2014)

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