OSA's Digital Library

Optics Letters

Optics Letters

| RAPID, SHORT PUBLICATIONS ON THE LATEST IN OPTICAL DISCOVERIES

  • Editor: Xi-Cheng Zhang
  • Vol. 39, Iss. 17 — Sep. 1, 2014
  • pp: 5006–5009

Photothermal laser speckle imaging

Caitlin Regan, Julio C. Ramirez-San-Juan, and Bernard Choi  »View Author Affiliations


Optics Letters, Vol. 39, Issue 17, pp. 5006-5009 (2014)
http://dx.doi.org/10.1364/OL.39.005006


View Full Text Article

Enhanced HTML    Acrobat PDF (387 KB)





Browse Journals / Lookup Meetings

Browse by Journal and Year


   


Lookup Conference Papers

Close Browse Journals / Lookup Meetings

Article Tools

Share
Citations

Abstract

The analysis of speckle contrast in a time-integrated speckle pattern enables visualization of superficial blood flow in exposed vasculature, a method we call laser speckle imaging (LSI). With current methods, LSI does not enable visualization of subsurface or small vasculature, because of optical scattering by stationary structures. In this work we propose a new technique called photothermal LSI to improve the visualization of blood vessels. A 595 nm laser pulse was used to excite blood in both in vitro and in vivo samples. The high absorption coefficient of blood at this wavelength results in efficient conversion of optical energy to thermal energy, resulting in an increase in the local temperature and hence increased scatterer motion, and thus a transient decrease in speckle contrast. As a result, we found that photothermal LSI was able to visualize blood vessels that were hidden when imaged with a conventional LSI system.

© 2014 Optical Society of America

OCIS Codes
(110.6150) Imaging systems : Speckle imaging
(350.5340) Other areas of optics : Photothermal effects
(110.0113) Imaging systems : Imaging through turbid media

ToC Category:
Imaging Systems

History
Original Manuscript: March 31, 2014
Revised Manuscript: June 9, 2014
Manuscript Accepted: July 7, 2014
Published: August 18, 2014

Virtual Issues
Vol. 9, Iss. 11 Virtual Journal for Biomedical Optics

Citation
Caitlin Regan, Julio C. Ramirez-San-Juan, and Bernard Choi, "Photothermal laser speckle imaging," Opt. Lett. 39, 5006-5009 (2014)
http://www.opticsinfobase.org/ol/abstract.cfm?URI=ol-39-17-5006


Sort:  Author  |  Year  |  Journal  |  Reset  

References

  1. A. F. Fercher and J. D. Briers, Opt. Commun. 37, 326 (1981). [CrossRef]
  2. A. K. Dunn, T. Bolay, M. A. Moskowitz, and D. A. Boas, J. Cereb. Bl. F. Metab. 21, 195 (2001). [CrossRef]
  3. J. J. Qiu, P. C. Li, W. H. Luo, J. Wang, H. Y. Zhang, and Q. M. Luo, J. Biomed. Opt. 15, 016003 (2010). [CrossRef]
  4. P. C. Li, S. L. Ni, L. Zhang, S. Q. Zeng, and Q. M. Luo, Opt. Lett. 31, 1824 (2006). [CrossRef]
  5. R. Liu, J. Qin, and R. K. K. Wang, J. Biomed. Opt. 18, 060508 (2013). [CrossRef]
  6. J. Kim, J. Oh, and B. Choi, J. Biomed. Opt. 15, 011110 (2010). [CrossRef]
  7. B. C. Li, B. Majaron, J. A. Viator, T. E. Milner, Z. P. Chen, Y. H. Zhao, H. W. Ren, and J. S. Nelson, J. Biomed. Opt. 9, 961 (2004). [CrossRef]
  8. S. A. Prahl, I. A. Vitkin, U. Burggemann, B. C. Wilson, and R. R. Anderson, Phys. Med. Biol. 37, 1203 (1992). [CrossRef]
  9. V. S. Kalambur, H. Mahaseth, J. C. Bischof, M. C. Kiebik, T. E. Welch, A. Vilback, D. J. Swanlund, R. P. Hebbel, J. D. Belcher, and G. M. Vercellotti, Am. J. Hematol. 77, 117 (2004). [CrossRef]
  10. O. Yang, D. Cuccia, and B. Choi, J. Biomed. Opt. 16, 016009 (2011). [CrossRef]
  11. A. J. Moy, S. M. White, E. S. Indrawan, J. Lotfi, M. J. Nudelman, S. J. Costantini, N. Agarwal, W. Jia, K. M. Kelly, B. S. Sorg, and B. Choi, Microvasc. Res. 82, 199 (2011). [CrossRef]
  12. B. Choi and A. J. Welch, Lasers Surg. Med. 29, 351 (2001). [CrossRef]
  13. S. A. Prahl, “Tabulated molar extinction coefficient for hemoglobin in water,” March4, 1998. http://omlc.ogi.edu/spectra/hemoglobin/summary.html .
  14. P. A. Hasgall, E. Neufeld, M. C. Gosselin, A. Klingenbock, and N. Kuster, “IT’IS Database for thermal and electromagnetic parameters of biological tissues,” Version 2.4, July30, 2013, www.itis.ethz.ch/database .
  15. T. B. Rice, E. Kwan, C. K. Hayakawa, A. J. Durkin, B. Choi, and B. J. Tromberg, Biomed. Opt. Express 4, 2880 (2013). [CrossRef]

Cited By

Alert me when this paper is cited

OSA is able to provide readers links to articles that cite this paper by participating in CrossRef's Cited-By Linking service. CrossRef includes content from more than 3000 publishers and societies. In addition to listing OSA journal articles that cite this paper, citing articles from other participating publishers will also be listed.

Figures

Fig. 1. Fig. 2. Fig. 3.
 

Supplementary Material


» Media 1: MP4 (266 KB)     
» Media 2: MP4 (481 KB)     

« Previous Article  |  Next Article »

OSA is a member of CrossRef.

CrossCheck Deposited