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Optics Letters

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  • Editor: Xi-Cheng Zhang
  • Vol. 39, Iss. 17 — Sep. 1, 2014
  • pp: 5192–5195

Near-infrared optical-resolution photoacoustic microscopy

Pengfei Hai, Junjie Yao, Konstantin I. Maslov, Yong Zhou, and Lihong V. Wang  »View Author Affiliations


Optics Letters, Vol. 39, Issue 17, pp. 5192-5195 (2014)
http://dx.doi.org/10.1364/OL.39.005192


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Abstract

Compared with visible light (380–700 nm), near-infrared light (700–1400 nm) undergoes weaker optical attenuation in biological tissue; thus, it can penetrate deeper. Herein, we demonstrate near-infrared optical-resolution photoacoustic microscopy (NIR-OR-PAM) with 1046 nm illumination. A penetration depth of 3.2 mm was achieved in chicken breast tissue ex vivo using optical fluence within the American National Standards Institute (ANSI) limit (100mJ/cm2). Beyond 0.6mm deep in chicken breast tissue, NIR-OR-PAM has shown finer resolution than the visible counterpart with 570 nm illumination. The deep imaging capability of NIR-OR-PAM was validated in both a mouse ear and a mouse brain. NIR-OR-PAM of possible lipid contrast was explored as well.

© 2014 Optical Society of America

OCIS Codes
(110.3080) Imaging systems : Infrared imaging
(170.5120) Medical optics and biotechnology : Photoacoustic imaging
(180.0180) Microscopy : Microscopy

ToC Category:
Medical Optics and Biotechnology

History
Original Manuscript: May 9, 2014
Revised Manuscript: July 25, 2014
Manuscript Accepted: August 1, 2014
Published: August 28, 2014

Citation
Pengfei Hai, Junjie Yao, Konstantin I. Maslov, Yong Zhou, and Lihong V. Wang, "Near-infrared optical-resolution photoacoustic microscopy," Opt. Lett. 39, 5192-5195 (2014)
http://www.opticsinfobase.org/ol/abstract.cfm?URI=ol-39-17-5192

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