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Optics Letters

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  • Editor: Xi-Cheng Zhang
  • Vol. 39, Iss. 2 — Jan. 15, 2014
  • pp: 303–306

1064  nm dispersive Raman spectroscopy of tissues with strong near-infrared autofluorescence

Chetan A. Patil, Isaac J. Pence, Chad A. Lieber, and Anita Mahadevan-Jansen  »View Author Affiliations


Optics Letters, Vol. 39, Issue 2, pp. 303-306 (2014)
http://dx.doi.org/10.1364/OL.39.000303


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Abstract

Raman spectroscopy is an established technique for molecularly specific characterization of tissues. However, even with near-infrared (NIR) excitation, some tissues possess background autofluorescence, which can overwhelm Raman scattering. Here, we report collection of spectra from tissues with strong autofluorescence using a 1064 nm system with a high-throughput dispersive spectrometer and deep-cooled InGaAs array. Spectra collected at 1064 nm were compared with those collected at 785 nm in specimens from human breast, liver, and kidney. The results demonstrate superior performance at 1064 nm in the liver and kidney, where NIR autofluorescence is intense. The results indicate the feasibility of new biomedical applications for Raman spectroscopy at 1064 nm in tissues with strong autofluorescence.

© 2014 Optical Society of America

OCIS Codes
(170.3890) Medical optics and biotechnology : Medical optics instrumentation
(170.5660) Medical optics and biotechnology : Raman spectroscopy
(170.6510) Medical optics and biotechnology : Spectroscopy, tissue diagnostics
(170.6935) Medical optics and biotechnology : Tissue characterization

ToC Category:
Medical Optics and Biotechnology

History
Original Manuscript: October 1, 2013
Manuscript Accepted: November 27, 2013
Published: January 8, 2014

Virtual Issues
Vol. 9, Iss. 3 Virtual Journal for Biomedical Optics

Citation
Chetan A. Patil, Isaac J. Pence, Chad A. Lieber, and Anita Mahadevan-Jansen, "1064  nm dispersive Raman spectroscopy of tissues with strong near-infrared autofluorescence," Opt. Lett. 39, 303-306 (2014)
http://www.opticsinfobase.org/ol/abstract.cfm?URI=ol-39-2-303

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