We propose a laser Doppler projection tomography (LDPT) method to obtain visualization of three-dimensional (3D) flowing structures. With LDPT, the flowing signal is extracted by a modified laser Doppler method, and the 3D flowing image is reconstructed by the filtered backprojection algorithm. Phantom experiments are performed to demonstrate that LDPT is able to obtain 3D flowing structure with higher signal-to-noise ratio and spatial resolution. Our experiment results display its potentially useful application to develop 3D label-free optical angiography for the circulation system of live small animal models or microfluidic experiments.
© 2014 Optical Society of America
Original Manuscript: October 14, 2013
Revised Manuscript: December 18, 2013
Manuscript Accepted: December 23, 2013
Published: February 10, 2014
Vol. 9, Iss. 4 Virtual Journal for Biomedical Optics
Yaguang Zeng, Ke Xiong, Xuanlong Lu, Guanping Feng, Dingan Han, and Jing Wu, "Laser Doppler projection tomography," Opt. Lett. 39, 904-906 (2014)