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Optics Letters

| RAPID, SHORT PUBLICATIONS ON THE LATEST IN OPTICAL DISCOVERIES

  • Editor: Xi-Cheng Zhang
  • Vol. 39, Iss. 7 — Apr. 1, 2014
  • pp: 1845–1848

Superficial radially resolved fluorescence and 3D photochemical time-dependent model for photodynamic therapy

Irene Salas-García, Félix Fanjul-Vélez, and José Luis Arce-Diego  »View Author Affiliations


Optics Letters, Vol. 39, Issue 7, pp. 1845-1848 (2014)
http://dx.doi.org/10.1364/OL.39.001845


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Abstract

Photodynamic therapy (PDT) dosimetric tools are crucial for treatment planning and noninvasive monitoring by means of fluorescence. Present approaches consider usually a 1D problem, a simple photochemical process, or a spatially homogeneous photosensitizer. In this work, a radially resolved superficial photosensitizer fluorescence and 3D photochemical time-dependent PDT model are presented. The model provides a time-dependent estimation of tissue fluorescence and the photosensitizer and singlet oxygen 3D concentrations. The model is applied to a basal cell carcinoma treated by Metvix topical photosensitizer protocol. The analysis shows the potentiality in treatment planning and monitoring. The fluorescence results are in agreement with previous measurements.

© 2014 Optical Society of America

OCIS Codes
(170.3660) Medical optics and biotechnology : Light propagation in tissues
(170.5180) Medical optics and biotechnology : Photodynamic therapy
(260.2510) Physical optics : Fluorescence
(260.5130) Physical optics : Photochemistry

ToC Category:
Physical Optics

History
Original Manuscript: December 19, 2013
Revised Manuscript: February 18, 2014
Manuscript Accepted: February 20, 2014
Published: March 21, 2014

Virtual Issues
Vol. 9, Iss. 6 Virtual Journal for Biomedical Optics

Citation
Irene Salas-García, Félix Fanjul-Vélez, and José Luis Arce-Diego, "Superficial radially resolved fluorescence and 3D photochemical time-dependent model for photodynamic therapy," Opt. Lett. 39, 1845-1848 (2014)
http://www.opticsinfobase.org/ol/abstract.cfm?URI=ol-39-7-1845


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