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Optics Letters

| RAPID, SHORT PUBLICATIONS ON THE LATEST IN OPTICAL DISCOVERIES

  • Editor: Xi-Cheng Zhang
  • Vol. 39, Iss. 8 — Apr. 15, 2014
  • pp: 2455–2458

In vivo OCT microangiography of rodent iris

Woo June Choi, Zhongwei Zhi, and Ruikang K. Wang  »View Author Affiliations


Optics Letters, Vol. 39, Issue 8, pp. 2455-2458 (2014)
http://dx.doi.org/10.1364/OL.39.002455


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Abstract

We report on the functional optical coherence tomography (OCT) imaging of iris tissue morphology and microcirculation in living small animals. Anterior segments of healthy mouse and rat eyes are imaged with high-speed spectral domain OCT (SD-OCT) utilizing ultrahigh sensitive optical microangiography (UHS-OMAG) imaging protocol. 3D iris microvasculature is produced by the use of an algorithm that calculates absolute differences between the amplitudes of the OCT interframes. We demonstrate that the UHS-OMAG is capable of delineating iris microvascular beds in the mouse and rat with capillary-level resolution. Furthermore, the fast imaging speed enables dynamic imaging of iris micro-vascular response during drug-induced pupil dilation. We believe that this OCT angiographic approach has a great potential for in situ and in vivo monitoring of the microcirculation within iris tissue beds in rodent disease models that have microvascular involvement.

© 2014 Optical Society of America

OCIS Codes
(170.4470) Medical optics and biotechnology : Ophthalmology
(170.4500) Medical optics and biotechnology : Optical coherence tomography
(170.2655) Medical optics and biotechnology : Functional monitoring and imaging

ToC Category:
Medical Optics and Biotechnology

History
Original Manuscript: January 7, 2014
Revised Manuscript: March 20, 2014
Manuscript Accepted: March 21, 2014
Published: April 11, 2014

Virtual Issues
Vol. 9, Iss. 6 Virtual Journal for Biomedical Optics

Citation
Woo June Choi, Zhongwei Zhi, and Ruikang K. Wang, "In vivo OCT microangiography of rodent iris," Opt. Lett. 39, 2455-2458 (2014)
http://www.opticsinfobase.org/ol/abstract.cfm?URI=ol-39-8-2455


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