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Optics Letters

Optics Letters


  • Editor: Xi-Cheng Zhang
  • Vol. 39, Iss. 9 — May. 1, 2014
  • pp: 2565–2568

Simultaneous optical absorption and viscoelasticity imaging based on photoacoustic lock-in measurement

Yue Zhao, Sihua Yang, Conggui Chen, and Da Xing  »View Author Affiliations

Optics Letters, Vol. 39, Issue 9, pp. 2565-2568 (2014)

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We propose a dual-parameter detection method to realize the simultaneous optical absorption and viscoelasticity imaging based on photoacoustic lock-in measurement. Both optical absorption and viscoelasticity properties can be obtained simultaneously by analyzing the amplitude and phase of photoacoustic signals. This method is experimentally verified by imaging of gelatin phantoms with different absorption coefficients and viscoelastic coefficients. Furthermore, pilot experiments were performed on an in vivo murine EMT6 tumor from the back of a BALB/c mouse. Results demonstrate that the method can be used to measure the optical absorption and viscoelasticity of different biological tissues.

© 2014 Optical Society of America

OCIS Codes
(120.5050) Instrumentation, measurement, and metrology : Phase measurement
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.5120) Medical optics and biotechnology : Photoacoustic imaging
(170.6935) Medical optics and biotechnology : Tissue characterization

ToC Category:
Medical Optics and Biotechnology

Original Manuscript: January 27, 2014
Revised Manuscript: March 17, 2014
Manuscript Accepted: March 22, 2014
Published: April 18, 2014

Virtual Issues
Vol. 9, Iss. 7 Virtual Journal for Biomedical Optics

Yue Zhao, Sihua Yang, Conggui Chen, and Da Xing, "Simultaneous optical absorption and viscoelasticity imaging based on photoacoustic lock-in measurement," Opt. Lett. 39, 2565-2568 (2014)

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