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Optics Letters

Optics Letters

| RAPID, SHORT PUBLICATIONS ON THE LATEST IN OPTICAL DISCOVERIES

  • Editor: Xi-Cheng Zhang
  • Vol. 39, Iss. 9 — May. 1, 2014
  • pp: 2790–2793

Laboratory x-ray fluorescence tomography for high-resolution nanoparticle bio-imaging

Hans M. Hertz, Jakob C. Larsson, Ulf Lundström, Daniel H. Larsson, and Carmen Vogt  »View Author Affiliations


Optics Letters, Vol. 39, Issue 9, pp. 2790-2793 (2014)
http://dx.doi.org/10.1364/OL.39.002790


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Abstract

We demonstrate that nanoparticle x-ray fluorescence computed tomography in mouse-sized objects can be performed with very high spatial resolution at acceptable dose and exposure times with a compact laboratory system. The method relies on the combination of the 24 keV line-emission from a high-brightness liquid-metal-jet x-ray source, pencil-beam-forming x-ray optics, photon-counting energy-dispersive detection, and carefully matched (Mo) nanoparticles. Phantom experiments and simulations show that the arrangement significantly reduces Compton background and allows 100 μm detail imaging at dose and exposure times compatible with small-animal experiments. The method provides a possible path to in vivo molecular x-ray imaging at sub-100 μm resolution in mice.

© 2014 Optical Society of America

OCIS Codes
(110.7440) Imaging systems : X-ray imaging
(170.7440) Medical optics and biotechnology : X-ray imaging
(340.7440) X-ray optics : X-ray imaging

ToC Category:
X-ray Optics

History
Original Manuscript: February 5, 2014
Revised Manuscript: April 4, 2014
Manuscript Accepted: April 7, 2014
Published: April 30, 2014

Virtual Issues
Vol. 9, Iss. 7 Virtual Journal for Biomedical Optics

Citation
Hans M. Hertz, Jakob C. Larsson, Ulf Lundström, Daniel H. Larsson, and Carmen Vogt, "Laboratory x-ray fluorescence tomography for high-resolution nanoparticle bio-imaging," Opt. Lett. 39, 2790-2793 (2014)
http://www.opticsinfobase.org/ol/abstract.cfm?URI=ol-39-9-2790

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