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Optics Letters

| RAPID, SHORT PUBLICATIONS ON THE LATEST IN OPTICAL DISCOVERIES

  • Editor: Xi-Cheng Zhang
  • Vol. 39, Iss. 9 — May. 1, 2014
  • pp: 2806–2809

Thermal therapeutic method for selective treatment of deep-lying tissue by combining laser and high-intensity focused ultrasound energy

Haemin Kim, Jeeun Kang, and Jin Ho Chang  »View Author Affiliations


Optics Letters, Vol. 39, Issue 9, pp. 2806-2809 (2014)
http://dx.doi.org/10.1364/OL.39.002806


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Abstract

Photothermal therapy is performed by delivering laser radiation into the target lesion containing tissue chromophores so as to induce localized heating. For high treatment efficacy, the laser wavelength should be selected to maximize the absorption of incident laser radiation in the tissue chromophores. However, even with the optimal laser wavelength, both the absorption and the scattering of laser energy in tissue openly hamper treatment efficacy in deep-lying lesions. To overcome the limitation, we propose a dual thermal therapeutic method in which both laser and acoustic energies are transmitted to increase therapeutic depth while maintaining high target selectivity of photothermal therapy. Through skin-mimicking phantom experiments, it was verified that the two different energies are complementary in elevation of tissue temperature, and the treatment depth using laser radiation is increased along with acoustic energy.

© 2014 Optical Society of America

OCIS Codes
(140.0140) Lasers and laser optics : Lasers and laser optics
(140.6810) Lasers and laser optics : Thermal effects
(170.0170) Medical optics and biotechnology : Medical optics and biotechnology
(170.5180) Medical optics and biotechnology : Photodynamic therapy
(170.7170) Medical optics and biotechnology : Ultrasound

ToC Category:
Medical Optics and Biotechnology

History
Original Manuscript: January 28, 2014
Revised Manuscript: March 27, 2014
Manuscript Accepted: April 6, 2014
Published: April 30, 2014

Virtual Issues
Vol. 9, Iss. 7 Virtual Journal for Biomedical Optics

Citation
Haemin Kim, Jeeun Kang, and Jin Ho Chang, "Thermal therapeutic method for selective treatment of deep-lying tissue by combining laser and high-intensity focused ultrasound energy," Opt. Lett. 39, 2806-2809 (2014)
http://www.opticsinfobase.org/ol/abstract.cfm?URI=ol-39-9-2806


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