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Optical Materials Express

Optical Materials Express

  • Editor: David J. Hagan
  • Vol. 2, Iss. 3 — Mar. 1, 2012
  • pp: 261–268

In vivo optical imaging with rare earth doped Ca2Si5N8 persistent luminescence nanoparticles

T. Maldiney, G. Sraiki, B. Viana, D. Gourier, C. Richard, D. Scherman, M. Bessodes, K. Van den Eeckhout, D. Poelman, and P. F. Smet  »View Author Affiliations

Optical Materials Express, Vol. 2, Issue 3, pp. 261-268 (2012)

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Ca2Si5N8:Eu2+,Tm3+ presents outstanding long lasting luminescence at about 610 nm. However, to be useful for in vivo optical imaging, persistent luminescence materials should possess high optical performance combined with sizes in the nanoscale. With this aim, we investigated two different techniques for the preparation of nanoparticles from Ca2Si5N8:Eu2+,Tm3+ bulk powder. First, nanoparticles were successfully prepared with the pulsed laser ablation method in liquid (abbreviated as PLAL). Secondly, nanoparticles obtained by selective sedimentation from the bulk compound resulted in satisfactory yield and allowed to perform the first real-time in vivo imaging with Ca2Si5N8:Eu2+,Tm3+ host. Finally the influence of surface functionalization on the biodistribution of the probe after systemic injection is discussed.

© 2012 OSA

OCIS Codes
(160.4670) Materials : Optical materials
(160.4760) Materials : Optical properties
(250.5230) Optoelectronics : Photoluminescence
(300.2140) Spectroscopy : Emission

ToC Category:
Fluorescent and Luminescent Materials

Original Manuscript: January 3, 2012
Revised Manuscript: January 31, 2012
Manuscript Accepted: February 6, 2012
Published: February 14, 2012

Virtual Issues
Persistent Phosphors (2012) Optical Materials Express

T. Maldiney, G. Sraiki, B. Viana, D. Gourier, C. Richard, D. Scherman, M. Bessodes, K. Van den Eeckhout, D. Poelman, and P. F. Smet, "In vivo optical imaging with rare earth doped Ca2Si5N8 persistent luminescence nanoparticles," Opt. Mater. Express 2, 261-268 (2012)

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