OpticsInfoBase

Tutorial on Optics in Neuroscience

• Abstract

• Biomedical Topical Meeting (BIO) 2006 paper: MA1
• Technical Digest (CD)
• Rector, David
• Full-text article is not available.

High-resolution functional optical imaging: sub-millimeter physiology of living tissue

• Abstract
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• Biomedical Topical Meeting (BIO) 2006 paper: MB1
• Technical Digest (CD)
• Hillman, Elizabeth M C; Bouchard, Matthew; Devor, Anna; de Crespigny, Alex; Boas, David A
• We have developed and applied new optical technologies for imaging the brain’s neuronal and hemodynamic responses to stimulus, including 3D high-resolution Laminar Optical...

Optofluidic Microscope-A Novel Microscope-on-a-Chip System

• Abstract
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• Biomedical Topical Meeting (BIO) 2006 paper: MB3
• Technical Digest (CD)
• Heng, Xin; Erickson, David; Baugh, Larry R; Yaqoob, Zahid; Sternberg, Paul W; Psaltis, Demetri; Yang, Changhuei
• We report the implementation of a novel microscope-on-a-chip system, termed the “Optofluidic Microscope (OFM)”. The OFM prototype is high resolution, compact and capable of...

In Vivo Quantification of Protein Interactions Using Lifetime Resolved FRET and FCS

• Abstract
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• Biomedical Topical Meeting (BIO) 2006 paper: MB4
• Technical Digest (CD)
• So, Peter T C; Pelet, Serge; Rahim, Nur Aida Abdul; Previte, Michael; Kamm, Roger D
• Microanalysis incorporating fluorescence lifetime-resolved resonance energy transfer and fluorescence correlation spectroscopy allows the kinetics and the thermodynamics of protein...

Spatially Resolved Measurement of Blood Oxygen Saturation in a Tissue Phantom Using Photoacoustic Spectroscopy

• Abstract
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• Biomedical Topical Meeting (BIO) 2006 paper: MC1
• Technical Digest (CD)
• Laufer, Jan; Elwell, Clare; Delpy, Dave; Beard, Paul
• Pulsed photoacoustic spectroscopy was used to make quantitative and spatially resolved measurements of blood oxygen saturation (SO2) in vitro with a performance comparable to that of...

Method for Recovering Quantitative Broadband Diffuse Optical Spectra from Layered Media

• Abstract
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• Biomedical Topical Meeting (BIO) 2006 paper: MC10
• Technical Digest (CD)
• Li, Ang; Kwong, Richard; Cerussi, Albert; Hayakawa, Carole; Tromberg, Bruce
• The recovery of broadband diffuse optical spectra of both layers in a two-layer phantom is reported for the first time. The recovery uses a diffusion equation solution with relative...

Non-Invasive Blood Analysis Using Raman Spectroscopy

• Abstract
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• Biomedical Topical Meeting (BIO) 2006 paper: MC2
• Technical Digest (CD)
• van der Voort, Marjolein; van Beek, Michiel; Lucassen, Gerald; de Bokx, Pieter; Rensen, Wouter; Engel, Jan
• We have developed a non-invasive blood analysis method based on combined imaging and confocal Raman spectroscopy. With this technology, in-vivo Raman spectra can be obtained that...

In vivo Study of Blood Glucose Concentration Prediction with Optical Coherence Tomography

• Abstract
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• Biomedical Topical Meeting (BIO) 2006 paper: MC3
• Technical Digest (CD)
• Sapozhnikova, Veronika; Kuranov, Roman; Prough, Donald; Cicenaite, Inga; Esenaliev, Rinat
• The capability of optical coherence tomography (OCT) to predict blood glucose concentration changes within physiological range was studied in vivo. Accuracy of 2 mM in prediction of...

Alterations in Regional Oxygen Saturation (StO2) and Blood Volume (HbT) in Infants With Brain Injuries and ECMO

• Abstract
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• Biomedical Topical Meeting (BIO) 2006 paper: MC4
• Technical Digest (CD)
• Grant, P Ellen; Themelis, George; Arvin, Kara; Thaker, Sonal; Krishnamoorthy, Kalpathy K; Bortfeld, Heather; Franceschini, Maria Angela
• To determine if quantitative regional StO2 and HbT measured with near infrared spectroscopy (NIRS) could detect differences between normal neonates and those with acute cerebral...

Real-Time Monitoring of Hemodynamic Changes in Neonatal Pig Brain with Head Trauma Injury

• Abstract
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• Biomedical Topical Meeting (BIO) 2006 paper: MC5
• Technical Digest (CD)
• Zhou, Chao; Durduran, Turgut; Yu, Guoqiang; Eucker, Stephanie; Friess, Stuart; Ichord, Rebecca; Margulies, Susan; Yodh, Arjun G
• Diffuse optical techniques were used to continuously monitor hemodynamic changes in piglet brains after traumatic head injury. The potential for using all optical methods for...

Modelling of Indocyanine Green Bolus with a Finite Element Model of the Adult Human Head and the Fick Principle

• Abstract
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• Biomedical Topical Meeting (BIO) 2006 paper: MC6
• Technical Digest (CD)
• Leung, Terence S; Tachtsidis, Ilias; Elwell, Clare E; Delpy, David T; Tisdall, Martin; Smith, Martin; Arridge, Simon
• Using the Fick principle and a finite element model of light distribution, ICG boluses were simulated in a head model, showing measurable changes in cerebral blood flow using NIR...

Intrinsic Raman Spectroscopy Improves Analyte Concentration Measurements in Turbid Media

• Abstract
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• Biomedical Topical Meeting (BIO) 2006 paper: MC7
• Technical Digest (CD)
• Shih, Wei-Chuan; Bechtel, Kate L; Feld, Michael S
• We present a new technique, intrinsic Raman spectroscopy, which utilizes diffuse reflectance to correct sample turbidity-induced distortions in Raman spectra. This technique allows...

3D Reconstruction of B-lymphocytes with Confocal Images and Parallel FDTD Simulations of Light Scattering

• Abstract
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• Biomedical Topical Meeting (BIO) 2006 paper: MC8
• Technical Digest (CD)
• Brock, Robert S; Hu, Xin-Hua; Weidner, Douglas A; Mourant, Judith R; Lu, Jun Q
• Mueller matrix elements of B-lymphocytes were obtained with reconstructed structures using a parallel FDTD code. By comparing with sphere models, we show that fine structure features...

Time-Resolved Multi-Wavelength Analysis for the Quantification of Chromophore Concentrations and Scattering Parameters in Turbid Media

• Abstract
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• Biomedical Topical Meeting (BIO) 2006 paper: MC9
• Technical Digest (CD)
• D'Andrea, Cosimo; Spinelli, Lorenzo; Bassi, Andrea; Giusto, Arianna; Contini, Davide; Swartling, Johannes; Torricelli, Alessandro; Cubeddu, Rinaldo
• We have developed and experimentally validated, on tissue-simulating phantoms and in-vivo, a time-resolved spectral fitting analysis for direct evaluation of chromophore...

Functional Imaging in Freely Moving Rats

• Abstract
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• Biomedical Topical Meeting (BIO) 2006 paper: MD1
• Technical Digest (CD)
• Barbour, Randall L; Pei, Yaling; Graber, Harry L; Ansari, Rehman; Schmitz, Christoph H; Holzer, Matthew; Barry, Jeremy; Muller, Robert
• We have developed an integrated DOT-EEG and behavioral recording system that provides, through a tethered head stage, concurrent recording in freely moving rats. Results show that...

Fast Optical Imaging of Neural Activation in Isolated Retina

• Abstract
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• Biomedical Topical Meeting (BIO) 2006 paper: MD10
• Technical Digest (CD)
• Yao, Xin-Cheng; George, John S
• We demonstrated fast imaging of activation in isolated frog retina using intrinsic optical responses associated with electrophysiological function. Dynamic optical responses were...

Neurovascular Coupling in the Rat Somatosensory Cortex: A Non-Invasive Diffuse Optical Imaging and Electroencephalography Study

• Abstract
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• Biomedical Topical Meeting (BIO) 2006 paper: MD2
• Technical Digest (CD)
• Franceschini, Maria Angela; Nissilä, Ilkka; Wu, Weicheng; Bonmassar, Giorgio; Boas, David A
• In this work we investigated the relationship between electrical and hemodynamic responses relating to neuronal activation. To this aim diffuse optical imaging and...

Functional Imaging of Rat Somatosensory Cortex using Optical Coherence Tomography

• Abstract
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• Biomedical Topical Meeting (BIO) 2006 paper: MD3
• Technical Digest (CD)
• Chen, Yu; Aguirre, Aaron D; Ruvinskaya, Lana; Devor, Anna; Boas, David A; Fujimoto, James G
• Simultaneous OCT and video microscopy were performed on rat somatosensory cortex during forepaw stimulation. Fractional changes in localized regions of OCT images reveal a functional...

Time Course of Activation of Human Occipital Cortex Measured with the Event-Related Optical Signal (EROS)

• Abstract
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• Biomedical Topical Meeting (BIO) 2006 paper: MD4
• Technical Digest (CD)
• Gratton, G; Low, K A; Maclin, E L; Brumback, C R; Gordon, B; Fabiani, Monica
• We recorded fast optical changes elicited by visual stimulation in occipital cortex from 19 young and 45 old human subjects. Faster propagation of activity from primary to secondary...

Diffuse Optical Tomography of Visual Cortex Activation in Humans

• Abstract
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• Biomedical Topical Meeting (BIO) 2006 paper: MD5
• Technical Digest (CD)
• Zeff, Benjamin W; Culver, Joseph P; Dehghani, Hamid
• We present diffuse optical tomography of brain activity in the human visual cortex. A new, high-density imaging instrument improves spatial sampling and allows better discrimination...