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Biomedical Optics (2010)

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  • Biomedical Optics (BIOMED) 2010 paper: BMA1
  • OSA Technical Digest (CD)
  • Nie, Shuming
  • Recent development in bioconjugated nanoparticles opens new opportunities for in-vivo molecular imaging and image-guided cancer surgery.

  • Biomedical Optics (BIOMED) 2010 paper: BMA2
  • OSA Technical Digest (CD)
  • Bednar, Bohumil
  • Molecular imaging biomarkers play a critical role in efforts to increase the probability of success of drug candidates, supporting validation of novel drug targets ...

  • Biomedical Optics (BIOMED) 2010 paper: BMA3
  • OSA Technical Digest (CD)
  • Xu, Chris
  • Deep tissue multiphoton microscopy (MPM) of mouse brain using 1280-nm excitation is presented. Several practical issues and a promising new femtosecond fiber source for long wavelength...

  • Biomedical Optics (BIOMED) 2010 paper: BMB1
  • OSA Technical Digest (CD)
  • Busch, David R; Guo, Wensheng; Choe, Regine; Durduran, Turgut; Rosen, Mark A; Schnall, Mitchell D; Putt, Mary E; Yodh, Arjun G
  • Diffuse Optical Tomography provides multi-parameter 3-D images of breast cancer. We introduce a multi-parameter, position, subject analysis to identify signatures of cancer and utilize...

  • Biomedical Optics (BIOMED) 2010 paper: BMB2
  • OSA Technical Digest (CD)
  • Carp, Stefan A; Roche-Labarbe, Nadege; Fang, Qianqian; Selb, Juliette J; Boas, David A
  • We use dynamic optical and MR imaging to characterize the hemodynamic behavior of breast tissue under external compression. Preliminary data shows spatial contrast in both optical...

  • Biomedical Optics (BIOMED) 2010 paper: BMB3
  • OSA Technical Digest (CD)
  • Kim, Anthony; Roy, Mathieu; Wilson, Brian C
  • We have developed a handheld fiberoptic probe for tissue fluorescence quantification and a technique to produce depth-resolved maps of sub-surface tumor fluorescence, to elaborate upon...

  • Biomedical Optics (BIOMED) 2010 paper: BMB4
  • OSA Technical Digest (CD)
  • Qiu, Le; Pleskow, Douglas; Chuttani, Ram; Vitkin, Edward; Itani, Sara; Guo, Lianyu; Goldsmith, Jeffrey; Modell, Mark; Itzkan, Irving; Hanlon, Eugene; Perelman, Lev
  • Endoscopic polarized scanning spectroscopic imaging provides real time information about morphology of epithelial tissue in gastrointestinal tract. This technique could lead to in vivo...

  • Biomedical Optics (BIOMED) 2010 paper: BMB5
  • OSA Technical Digest (CD)
  • Gruber, Josiah D; Paliwal, Akshat; Ghadyani, Hamid; Maytin, Edward; Hasan, Tayyaba; Pogue, Brian
  • An automated ultrasound-guided fluorescence tomography system was created to image the Protoporphyrin IX production of subcutaneous tumors in vivo. Negative production and positive...

  • Biomedical Optics (BIOMED) 2010 paper: BMB6
  • OSA Technical Digest (CD)
  • Li, Changqing; Bec, Julien; Cherry, Simon R
  • We have built a simultaneous positron emission tomography and three-dimensional fluorescence optical tomography system for small animal imaging, and performed in vivo experiments....

  • Biomedical Optics (BIOMED) 2010 paper: BMB7
  • OSA Technical Digest (CD)
  • Hennesy, Ricky; Jacques, Steve; Pellacani, Giovanni; Gareau, Daniel S
  • Melanoma arises in the basal layer of the skin located within the penetration limits of confocal microscopy. From confocal pathological traits, we created a computer algorithm to...

  • Biomedical Optics (BIOMED) 2010 paper: BMB8
  • OSA Technical Digest (CD)
  • Pekar, Julius; Patterson, Michael S
  • We describe the development an integrated x-ray CT and bioluminescence tomography imaging system. Reconstructions of optical properties using CT spatial priors are presented with...

  • Biomedical Optics (BIOMED) 2010 paper: BMC1
  • OSA Technical Digest (CD)
  • Labroille, Guillaume; Pillai, Rajesh S; Boudoux, Caroline; Olivier, Nicolas; Solinas, Xavier; Joffre, Manuel; Beaurepaire, Emmanuel
  • We report multiplexed two-photon imaging in vivo with fast pixel rates and micrometer resolution. Using coherent control of the two-photon excited fluorescence, we performed selective...

  • Biomedical Optics (BIOMED) 2010 paper: BMC2
  • OSA Technical Digest (CD)
  • Farrar, Matthew J; Renninger, William; Fetcho, Joseph R; Wise, Frank W; Schaffer, Chris B
  • We demonstrate that third harmonic generation provides a suitable modality for imaging myelination on axons in the mouse brain and spinal cord with micrometer resolution both in vivo...

  • Biomedical Optics (BIOMED) 2010 paper: BMC3
  • OSA Technical Digest (CD)
  • Wu, Yicong; Xi, Jiefeng; Li, Xingde
  • We report on a fiber-optic scanning endomicroscopy system based on a customized double-clad fiber (DCF) and a miniature compound lens that enables two-photon autofluorescence imaging...

  • Biomedical Optics (BIOMED) 2010 paper: BMC4
  • OSA Technical Digest (CD)
  • Cha, Jae Won; Chen, Jerry L; Nedivi, Elly; So, Peter T
  • For imaging multiple fluorophores, spectral decomposition is often necessary due to the spectral overlap of emission signals. While decomposition techniques have been developed,...

  • Biomedical Optics (BIOMED) 2010 paper: BMC5
  • OSA Technical Digest (CD)
  • Xylas, Joanna; Alt-Holland, Addy; Hunter, Martin; Levitt, Jonathan M; Garlick, Jonathan; Georgakoudi, Irene
  • Intrinsic two-photon excited fluorescence (TPEF) images of epithelial tumor cells embedded in collagen matrices reveal distinct morphologies and organization from the subcellular to...

  • Biomedical Optics (BIOMED) 2010 paper: BMC6
  • OSA Technical Digest (CD)
  • Nguyen, John; Nishimura, Nozomi; Iadecola, Costantino; Schaffer, Chris B
  • Femtosecond laser induced photodisruption is used to clot single venules in live, anesthetized rats. Two-photon excited fluorescence imaging shows significant decreases in blood flow...

  • Biomedical Optics (BIOMED) 2010 paper: BMC7
  • OSA Technical Digest (CD)
  • Chia, Thomas; Levene, Michael J
  • Microprisms inserted into the cortex of mouse enable in vivo multiphoton microscopy, rotating the field-of-view from parallel to perpendicular to the surface of cortex and allowing...

  • Biomedical Optics (BIOMED) 2010 paper: BMD1
  • OSA Technical Digest (CD)
  • Egner, Alexander
  • The resolution of conventional light microscopy is limited by diffraction. The principles of common methods to overcome the diffraction barrier and examples about their implementation...

  • Biomedical Optics (BIOMED) 2010 paper: BMD2
  • OSA Technical Digest (CD)
  • Pavani, Sri Rama Prasanna; DeLuca, Jennifer G; Piestun, Rafael
  • We demonstrate polarization sensitive detection with 3-D super-localization of single-molecules and unveil 3-D polarization specific characteristics of single-molecules within the...
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