OpticsInfoBase

Nanotechnology for Molecular Imaging and Image-Guided Surgery

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• Biomedical Optics (BIOMED) 2010 paper: BMA1
• OSA Technical Digest (CD)
• Nie, Shuming
• Recent development in bioconjugated nanoparticles opens new opportunities for in-vivo molecular imaging and image-guided cancer surgery.

Development of Optical Imaging Biomarkers and Applications in Drug Discovery and Development

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• Biomedical Optics (BIOMED) 2010 paper: BMA2
• OSA Technical Digest (CD)
• Bednar, Bohumil
• Molecular imaging biomarkers play a critical role in efforts to increase the probability of success of drug candidates, supporting validation of novel drug targets ...

Technology Development for Deep Tissue Multiphoton Imaging

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• Biomedical Optics (BIOMED) 2010 paper: BMA3
• OSA Technical Digest (CD)
• Xu, Chris
• Deep tissue multiphoton microscopy (MPM) of mouse brain using 1280-nm excitation is presented. Several practical issues and a promising new femtosecond fiber source for long wavelength...

Computer-Aided Detection of Tumors in 3-D Tomograms from Diffuse Optical Mammography

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• Biomedical Optics (BIOMED) 2010 paper: BMB1
• OSA Technical Digest (CD)
• Busch, David R; Guo, Wensheng; Choe, Regine; Durduran, Turgut; Rosen, Mark A; Schnall, Mitchell D; Putt, Mary E; Yodh, Arjun G
• Diffuse Optical Tomography provides multi-parameter 3-D images of breast cancer. We introduce a multi-parameter, position, subject analysis to identify signatures of cancer and utilize...

Multi-Modality Imaging of the Compressed Breast

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• Biomedical Optics (BIOMED) 2010 paper: BMB2
• OSA Technical Digest (CD)
• Carp, Stefan A; Roche-Labarbe, Nadege; Fang, Qianqian; Selb, Juliette J; Boas, David A
• We use dynamic optical and MR imaging to characterize the hemodynamic behavior of breast tissue under external compression. Preliminary data shows spatial contrast in both optical...

Quantitative and Depth-Resolved Fluorescence Techniques for Intraoperative Guidance of Brain Tumor Resection Surgery

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• Biomedical Optics (BIOMED) 2010 paper: BMB3
• OSA Technical Digest (CD)
• Kim, Anthony; Roy, Mathieu; Wilson, Brian C
• We have developed a handheld fiberoptic probe for tissue fluorescence quantification and a technique to produce depth-resolved maps of sub-surface tumor fluorescence, to elaborate upon...

Endoscopic Polarized Scanning Spectroscopic Imaging of Barrett’s Esophagus in vivo

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• Biomedical Optics (BIOMED) 2010 paper: BMB4
• OSA Technical Digest (CD)
• Qiu, Le; Pleskow, Douglas; Chuttani, Ram; Vitkin, Edward; Itani, Sara; Guo, Lianyu; Goldsmith, Jeffrey; Modell, Mark; Itzkan, Irving; Hanlon, Eugene; Perelman, Lev
• Endoscopic polarized scanning spectroscopic imaging provides real time information about morphology of epithelial tissue in gastrointestinal tract. This technique could lead to in vivo...

High-Frequency Ultrasound-Guided Fluorescence Tomography of Protoporphyrin IX in Subcutaneous Tumors

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• Biomedical Optics (BIOMED) 2010 paper: BMB5
• OSA Technical Digest (CD)
• Gruber, Josiah D; Paliwal, Akshat; Ghadyani, Hamid; Maytin, Edward; Hasan, Tayyaba; Pogue, Brian
• An automated ultrasound-guided fluorescence tomography system was created to image the Protoporphyrin IX production of subcutaneous tumors in vivo. Negative production and positive...

Simultaneous PET and 3-D Fluorescence Optical Tomography for Small Animal Imaging: In vivo Results and System Improvements

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• Biomedical Optics (BIOMED) 2010 paper: BMB6
• OSA Technical Digest (CD)
• Li, Changqing; Bec, Julien; Cherry, Simon R
• We have built a simultaneous positron emission tomography and three-dimensional fluorescence optical tomography system for small animal imaging, and performed in vivo experiments....

Automated Confocal Detection of Malignant Melanoma

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• Biomedical Optics (BIOMED) 2010 paper: BMB7
• OSA Technical Digest (CD)
• Hennesy, Ricky; Jacques, Steve; Pellacani, Giovanni; Gareau, Daniel S
• Melanoma arises in the basal layer of the skin located within the penetration limits of confocal microscopy. From confocal pathological traits, we created a computer algorithm to...

Multispectral Bioluminescence Tomography: Simulations and Phantom Studies with a Priori X-Ray CT Spatial Priors

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• Biomedical Optics (BIOMED) 2010 paper: BMB8
• OSA Technical Digest (CD)
• Pekar, Julius; Patterson, Michael S
• We describe the development an integrated x-ray CT and bioluminescence tomography imaging system. Reconstructions of optical properties using CT spatial priors are presented with...

Two-Photon Microscopy of Biological Organisms with Shaped Broadband Pulses

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• Biomedical Optics (BIOMED) 2010 paper: BMC1
• OSA Technical Digest (CD)
• Labroille, Guillaume; Pillai, Rajesh S; Boudoux, Caroline; Olivier, Nicolas; Solinas, Xavier; Joffre, Manuel; Beaurepaire, Emmanuel
• We report multiplexed two-photon imaging in vivo with fast pixel rates and micrometer resolution. Using coherent control of the two-photon excited fluorescence, we performed selective...

Third Harmonic Generation as a Novel Technique for Imaging Myelin in the Central Nervous System

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• Biomedical Optics (BIOMED) 2010 paper: BMC2
• OSA Technical Digest (CD)
• Farrar, Matthew J; Renninger, William; Fetcho, Joseph R; Wise, Frank W; Schaffer, Chris B
• We demonstrate that third harmonic generation provides a suitable modality for imaging myelination on axons in the mouse brain and spinal cord with micrometer resolution both in vivo...

Fiber-Optic Nonlinear Endomicrocopy for Intrinsic Imaging of Biological Tissues

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• Biomedical Optics (BIOMED) 2010 paper: BMC3
• OSA Technical Digest (CD)
• Wu, Yicong; Xi, Jiefeng; Li, Xingde
• We report on a fiber-optic scanning endomicroscopy system based on a customized double-clad fiber (DCF) and a miniature compound lens that enables two-photon autofluorescence imaging...

Spectral Decomposition of Multicolor Imaging in Multifocal Multiphoton Microscopy

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• Biomedical Optics (BIOMED) 2010 paper: BMC4
• OSA Technical Digest (CD)
• Cha, Jae Won; Chen, Jerry L; Nedivi, Elly; So, Peter T
• For imaging multiple fluorophores, spectral decomposition is often necessary due to the spectral overlap of emission signals. While decomposition techniques have been developed,...

Optical Biomarkers Associated with the Invasive Potential of Tumor Cells in Engineered Tissue Models

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• Biomedical Optics (BIOMED) 2010 paper: BMC5
• OSA Technical Digest (CD)
• Xylas, Joanna; Alt-Holland, Addy; Hunter, Martin; Levitt, Jonathan M; Garlick, Jonathan; Georgakoudi, Irene
• Intrinsic two-photon excited fluorescence (TPEF) images of epithelial tumor cells embedded in collagen matrices reveal distinct morphologies and organization from the subcellular to...

Femtosecond Laser Ablation to Induce Occlusions in Single, Targeted Venules in Rat Brain

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• Biomedical Optics (BIOMED) 2010 paper: BMC6
• OSA Technical Digest (CD)
• Nguyen, John; Nishimura, Nozomi; Iadecola, Costantino; Schaffer, Chris B
• Femtosecond laser induced photodisruption is used to clot single venules in live, anesthetized rats. Two-photon excited fluorescence imaging shows significant decreases in blood flow...

Microprisms for in vivo Multiphoton Microscopy of Mouse Cortex

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• Biomedical Optics (BIOMED) 2010 paper: BMC7
• OSA Technical Digest (CD)
• Chia, Thomas; Levene, Michael J
• Microprisms inserted into the cortex of mouse enable in vivo multiphoton microscopy, rotating the field-of-view from parallel to perpendicular to the surface of cortex and allowing...

Developments in Fluorescence Nanoscopy

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• Biomedical Optics (BIOMED) 2010 paper: BMD1
• OSA Technical Digest (CD)
• Egner, Alexander
• The resolution of conventional light microscopy is limited by diffraction. The principles of common methods to overcome the diffraction barrier and examples about their implementation...

Polarization Sensitive Three-Dimensional Nanoscopy with a Double-Helix Microscope

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• Biomedical Optics (BIOMED) 2010 paper: BMD2
• OSA Technical Digest (CD)
• Pavani, Sri Rama Prasanna; DeLuca, Jennifer G; Piestun, Rafael
• We demonstrate polarization sensitive detection with 3-D super-localization of single-molecules and unveil 3-D polarization specific characteristics of single-molecules within the...