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Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics

| EXPLORING THE INTERFACE OF LIGHT AND BIOMEDICINE

  • Editor: Gregory W. Faris
  • Vol. 1, Iss. 6 — Jun. 13, 2006

Two-dimensional bioluminescence tomography: numerical simulations and phantom experiments

Senhu Li, Qizhi Zhang, and Huabei Jiang  »View Author Affiliations


Applied Optics, Vol. 45, Issue 14, pp. 3390-3394 (2006)
http://dx.doi.org/10.1364/AO.45.003390


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Abstract

The reconstruction of internal light sources in bioluminescence tomography (BLT) is a challenging inverse problem because of the limited amount of information available compared with that for other kinds of tomography such as fluorescence tomography in which external illumination sources are used. We demonstrated previously, using phantom experiments, that a target containing luciferases could be detected tomographically when the target was located relatively close to the imaging boundary. Here we describe an improved BLT reconstruction method that can detect luciferase-containing targets located anywhere within an imaging domain. The method is tested with numerical simulations and further confirmed with several phantom experiments.

© 2006 Optical Society of America

OCIS Codes
(110.6960) Imaging systems : Tomography
(170.3010) Medical optics and biotechnology : Image reconstruction techniques

History
Original Manuscript: August 22, 2005
Revised Manuscript: November 22, 2005
Manuscript Accepted: November 28, 2005

Virtual Issues
Vol. 1, Iss. 6 Virtual Journal for Biomedical Optics

Citation
Senhu Li, Qizhi Zhang, and Huabei Jiang, "Two-dimensional bioluminescence tomography: numerical simulations and phantom experiments," Appl. Opt. 45, 3390-3394 (2006)
http://www.opticsinfobase.org/vjbo/abstract.cfm?URI=ao-45-14-3390

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