Analytical solution for light propagation in a two-layer tissue structure with a tilted interface for breast imaging
Applied Optics, Vol. 45, Issue 20, pp. 5027-5036 (2006)
http://dx.doi.org/10.1364/AO.45.005027
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Abstract
Reflectance measurement of breast tissue is influenced by the underlying chest wall, which is often tilted as seen by the detection probe. We develop an analytical solution of light propagation in a two-layer tissue structure with tilted interface and refractive index difference between the layers. We validate the analytical solution with Monte Carlo simulations and phantom experiments, and a good agreement is seen. The influence of varying the tilting angle of the interface on the reflectance is discussed for two types of layered structures. Further, we apply the developed analytical solution to obtain the optical properties of breast tissue and chest wall from clinical data. Inverse calculation using the developed solution applied to the data obtained from Monte Carlo simulations shows that the optical properties of both layers are obtained with higher accuracy as compared to using a simple two-layer model ignoring the interface tilt. This is expected to improve the accuracy in estimating the optical properties of breast tissue, thus enhancing the accuracy of optical tomography of breast tumors.
© 2006 Optical Society of America
OCIS Codes
(170.3660) Medical optics and biotechnology : Light propagation in tissues
(170.5270) Medical optics and biotechnology : Photon density waves
History
Original Manuscript: August 16, 2005
Revised Manuscript: December 3, 2005
Manuscript Accepted: January 27, 2006
Virtual Issues
Vol. 1, Iss. 8 Virtual Journal for Biomedical Optics
Citation
Mini Das, Chen Xu, and Quing Zhu, "Analytical solution for light propagation in a two-layer tissue structure with a tilted interface for breast imaging," Appl. Opt. 45, 5027-5036 (2006)
http://www.opticsinfobase.org/vjbo/abstract.cfm?URI=ao-45-20-5027
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