Nanoparticle-based photonic explorers have been developed for intracellular sensing and photodynamic therapy (PDT). The design employs nanoparticles made of various matrices as multifunctional nanoplatforms, loading active components by encapsulation or covalent attachment. The nanoplatform for biosensing has been successfully applied to intracellular measurements of important ionic and molecular species. The nanoplatform for PDT has shown high therapeutic efficacy in a rat 9L gliosarcoma model. Specifically, a multifunctional nanoplatform that encompasses magnetic resonance imaging (MRI) and PDT agents inside, as well as targeting ligands on the surface, has been developed and applied in vivo, resulting in much improved MRI contrast enhancement and PDT efficacy.
© 2007 Optical Society of America
Original Manuscript: June 30, 2006
Revised Manuscript: October 13, 2006
Manuscript Accepted: October 16, 2006
Published: March 13, 2007
Vol. 2, Iss. 5 Virtual Journal for Biomedical Optics
Yong-Eun Lee Koo, Wenzhe Fan, Hoejin Hah, Hao Xu, Dan Orringer, Brian Ross, Alnawaz Rehemtulla, Martin A. Philbert, and Raoul Kopelman, "Photonic explorers based on multifunctional nanoplatforms for biosensing and photodynamic therapy," Appl. Opt. 46, 1924-1930 (2007)