OSA's Digital Library

Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics

| EXPLORING THE INTERFACE OF LIGHT AND BIOMEDICINE

  • Editor: Gregory W. Faris
  • Vol. 3, Iss. 6 — Jun. 17, 2008

Measurement of diffuse photon-pairs density wave in a multiple-scattering medium

Li-Ping Yu, Chien Chou, Jheng-Syong Wu, and Yi-Hsin Chan  »View Author Affiliations


Applied Optics, Vol. 47, Issue 14, pp. 2708-2714 (2008)
http://dx.doi.org/10.1364/AO.47.002708


View Full Text Article

Enhanced HTML    Acrobat PDF (1318 KB)





Browse Journals / Lookup Meetings

Browse by Journal and Year


   


Lookup Conference Papers

Close Browse Journals / Lookup Meetings

Article Tools

Share
Citations

Abstract

As a continuation of the previously developed theory of a diffuse photon-pairs density wave (DPPDW) [ Appl. Opt. 44, 1416–1425 (2005)], this research experimentally studies and verifies the DPPDW theory in a heterogeneous multiple-scattering medium. The DPPDW is generated by collecting the scattered linear polarized photon pairs (LPPPs) in the multiple-scattering medium. Theoretically, the common-path propagation of LPPPs not only provides common phase noise rejection mode but also performs coherence technique via heterodyne detection. In addition, the polarization gating and spatial coherence gating of LPPPs would suppress the severe scattered photon in the multiple-scattering medium. In the experiment, the amplitude and phase wavefronts of DPPDWs, which are distorted by a small object embedded in a homogeneous multiple-scattering medium, are measured in one dimension or two dimensions by scanning the source detector pair. The measured distortion of DPPDW wavefronts are detected precisely and are consistent with the theoretical calculation of DPPDW. It implies an improvement on the detection sensitivity of a small object compared with the conventional diffuse photon density wave (DPDW).

© 2008 Optical Society of America

OCIS Codes
(170.4090) Medical optics and biotechnology : Modulation techniques
(170.5270) Medical optics and biotechnology : Photon density waves
(290.4210) Scattering : Multiple scattering

ToC Category:
Medical Optics and Biotechnology

History
Original Manuscript: December 3, 2007
Revised Manuscript: April 17, 2008
Manuscript Accepted: April 18, 2008
Published: May 8, 2008

Virtual Issues
Vol. 3, Iss. 6 Virtual Journal for Biomedical Optics

Citation
Li-Ping Yu, Chien Chou, Jheng-Syong Wu, and Yi-Hsin Chan, "Measurement of diffuse photon-pairs density wave in a multiple-scattering medium," Appl. Opt. 47, 2708-2714 (2008)
http://www.opticsinfobase.org/vjbo/abstract.cfm?URI=ao-47-14-2708


Sort:  Author  |  Year  |  Journal  |  Reset  

References

  1. T. Vo-Dinh, Biomedical Photonics Handbook (SPIE, 2003). [CrossRef]
  2. V. V. Tuchin, Tissue Optics: Light Scattering Methods and Instruments for Medical Diagnosis, 2nd ed. (SPIE, 2007).
  3. A. J. Welch and M. J. C. van Gemert, Optical-Thermal Response of Laser-Irradiated Tissue, (Springer, 1995).
  4. D. A. Boas, D. H. Brooks, E. L. Miller, C. A. DiMarzio, M. Kilmer, R. J. Gaudette, and Q. Zhang, “Imaging the body with diffuse optical tomography,” IEEE Signal Process Mag. 18, 57-75(2001). [CrossRef]
  5. V. Ntziachristos and B. Chance, “Probing physiology and molecular function using optical imaging: applications to breast cancer,” Breast Cancer Res. 3, 41-46 (2001). [CrossRef] [PubMed]
  6. S. R. Arridge, “Optical tomography in medical imaging,” Inverse Probl. 15, 41-93 (1999). [CrossRef]
  7. B. J. Tromberg, L. O. Svaasand, T. T. Tsay, and R. C. Haskell, “Properties of photon density waves in multiple-scattering media,” Appl. Opt. 32, 607-616 (1993). [CrossRef] [PubMed]
  8. D. A. Boas, M. A. O'Leary, B. Chance, and A. G. Yodh, “Scattering of diffuse photon density waves by spherical inhomogeneities within turbid media: analytic solution and applications,” in Proc. Natl. Acad. Sci. USA 91, 4887-4891(1994). [CrossRef] [PubMed]
  9. D. A. Boas, M. A. O'Leary, B. Chance, and A. G. Yodh, “Detection and characterization of optical inhomogeneities with diffuse photon density waves: a signal-to-noise analysis,” Appl. Opt. 36, 75-92 (1997). [CrossRef] [PubMed]
  10. S. A. Walker, D. A. Boas, and E. Gratton, “Photon density waves scattered from cylindrical inhomogeneities: theory and experiments,” Appl. Opt. 37, 1935-1944 (1998). [CrossRef]
  11. Y. Chen, C. Mu, X. Intes, and B. Chance, “Signal-to-noise analysis for detection sensitivity of small absorbing heterogeneity in turbid media with single-source and dual-interfering-source,” Opt. Express 9, 212-224 (2001). [CrossRef] [PubMed]
  12. Y. H. Chan, C. Chou, J. S. Wu, H. F. Chang, and H. F. Yau, “Properties of a diffused photon-pair density wave in a multiple-scattering medium,” Appl. Opt. 44, 1416-1425 (2005). [CrossRef] [PubMed]
  13. L. C. Peng, C. Chou, C. W. Lyu, and J. C. Hsieh, “Zeeman laser-scanning confocal microscopy in turbid media,” Opt. Lett. 26, 349-351 (2001). [CrossRef]
  14. C. Chou, L. C. Peng, Y. H. Chou, Y. H. Tang, C. Y. Han, and C. W. Lyu, “Polarized optical coherence imaging in turbid media by use of a Zeeman laser,” Opt. Lett. 25, 1517-1519 (2000). [CrossRef]
  15. H. J. van Staveren, C. J. M. Moes, J. van Marie, S. A. Prahl, and M. J. C. van Gemert, “Light scattering in Intralipid-10% in the wavelength range of 400-1100 nm,” Appl. Opt. 30, 4507-4514 (1991). [CrossRef] [PubMed]
  16. T. H. Pharm, O. Coquz, J. B. Fishkin, E. Anderson, and B. J. Tromberg, “Broad bandwidth frequency domain instrument for quantitative tissue optical spectroscopy,” Rev. Sci. Instrum. 71, 2500-2513 (2000). [CrossRef]
  17. Y. Chen, C. Mu, X. Intes, and B. Chance, “Signal-to-noise analysis for detection sensitivity of small absorbing heterogeneity in turbid media with single-source and dual-interfering-source,” Opt. Express 9, 212-224 (2001). [CrossRef] [PubMed]
  18. D. A. Boas, “diffuse photon density waves,” http://omlc.ogi.edu/software/density/index.html.
  19. X. Li, B. Chance, and A. G. Yodh, “Fluorescent heterogeneities in turbid media: limits for detection, characterization, and comparison with absorption,” Appl. Opt. 37, 6833-6844 (1998) [CrossRef]
  20. K. C. Hadley and I. A. Vitkin, “Optical rotation and linear and circular depolarization rates in diffusively scattered light from chiral, racemic, and achiral turbid media,” J. Biomed. Opt. 7, 291-299 (2002). [CrossRef] [PubMed]

Cited By

Alert me when this paper is cited

OSA is able to provide readers links to articles that cite this paper by participating in CrossRef's Cited-By Linking service. CrossRef includes content from more than 3000 publishers and societies. In addition to listing OSA journal articles that cite this paper, citing articles from other participating publishers will also be listed.


« Previous Article  |  Next Article »

OSA is a member of CrossRef.

CrossCheck Deposited