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Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics

| EXPLORING THE INTERFACE OF LIGHT AND BIOMEDICINE

  • Editor: Gregory W. Faris
  • Vol. 5, Iss. 1 — Jan. 4, 2010

Optimizing the spatial resolution of photonic crystal label-free imaging

Ian D. Block, Patrick C. Mathias, Sarah I. Jones, Lila O. Vodkin, and Brian T. Cunningham  »View Author Affiliations


Applied Optics, Vol. 48, Issue 34, pp. 6567-6574 (2009)
http://dx.doi.org/10.1364/AO.48.006567


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Abstract

A theory is derived to describe the relationship between photonic crystal (PC) label-free imaging resolution and PC resonance spectral linewidth and location. PCs are fabricated and patterned with a res olution standard photomask in order to verify this relationship experimentally. Two distinct linear resolutions of < 1 μm and 3.5 μm are demonstrated in orthogonal directions on a single device, where the former is limited by the imaging system optics and the latter is constrained by finite resonant mode propagation. In order to illustrate the utility of improved design control, the spectral response of a PC is optimized for label-free imaging of immobilized DNA capture spots on a microarray.

© 2009 Optical Society of America

OCIS Codes
(280.1415) Remote sensing and sensors : Biological sensing and sensors
(050.5298) Diffraction and gratings : Photonic crystals

ToC Category:
Imaging Systems

History
Original Manuscript: June 19, 2009
Revised Manuscript: October 17, 2009
Manuscript Accepted: November 2, 2009
Published: November 20, 2009

Virtual Issues
Vol. 5, Iss. 1 Virtual Journal for Biomedical Optics

Citation
Ian D. Block, Patrick C. Mathias, Sarah I. Jones, Lila O. Vodkin, and Brian T. Cunningham, "Optimizing the spatial resolution of photonic crystal label-free imaging," Appl. Opt. 48, 6567-6574 (2009)
http://www.opticsinfobase.org/vjbo/abstract.cfm?URI=ao-48-34-6567


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References

  1. A. J. Cunningham, Introduction to Bioanalytical Sensors (Wiley-Interscience, 1998).
  2. M. Schena, Microarray Analysis (Wiley-Liss, 2002).
  3. H. Zhu, M. Bilgin, R. Bangham, D. Hall, A. Casamayor, P. Bertone, N. Lan, R. Jansen, S. Bidlingmaier, T. Houfek, T. Mitchell, P. Miller, R. A. Dean, M. Gerstein, and M. Snyder, “Global analysis of protein activities using proteome chips,” Science 293, 2101-2105 (2001). [CrossRef] [PubMed]
  4. J. S. Shumaker-Parry and C. T. Campbell, “Quantitative methods for spatially resolved adsorption/desorption measurements in real time by surface plasmon resonance microscopy,” Anal. Chem. 76, 907-917 (2004). [CrossRef] [PubMed]
  5. X. Zhu, J. P. Landry, Y.-S. Sun, J. P. Gregg, K. S. Lam, and X. Guo, “Oblique-incidence reflectivity difference microscope for label-free high-throughput detection of biochemical reactions in a microarray format,” Appl. Opt. 46, 1890-1895 (2007). [CrossRef] [PubMed]
  6. E. Ozkumur, J. W. Needham, D. A. Bergstein, R. Gonzalez, M. Cabodi, J. M. Gershoni, B. B. Goldberg, and M. S. Unlu, “Label-free and dynamic detection of biomolecular interactions for high-throughput microarray applications,” Proc. Natl. Acad. Sci. USA 105, 7988-7992 (2008). [CrossRef] [PubMed]
  7. P. C. Mathias, N. Ganesh, L. L. Chan, and B. T. Cunningham, “Label-free assays on the BIND system,” J. Biomol. Screen. 9, 481-490 (2004). [CrossRef]
  8. L. L. Chan, M. F. Pineda, J. Heeres, P. Hergenrother, and B. T. Cunningham, “General method for discovering inhibitors of protein-DNA interactions using photonic crystal biosensors,” ACS Chem. Biol. 3, 437-448 (2008). [CrossRef] [PubMed]
  9. M. F. Pineda, L. L. Chan, T. Kuhlenschmidt, M. Kuhlenschmidt, and B. T. Cunningham, “Rapid label-free selective detection of porcine rotavirus using photonic crystal biosensors for groundwater monitoring,” IEEE Sens. J. 9, 470-477 (2009). [CrossRef]
  10. D. Rosenblatt, A. Sharon and A. A. Friesem, “Resonant grating waveguide structures,” IEEE J. Quantum Electron. 33, 2038-2059 (1997). [CrossRef]
  11. P. Li, B. Lin, J. Gerstenmaier, and B. T. Cunningham, “A new method for label-free imaging of biomolecular interactions,” Sens. Actuators B 99, 6-13 (2004). [CrossRef]
  12. L. L. Chan, P. Y. Li, D. Puff, and B. T. Cunningham, “A self-referencing method for microplate label-free photonic crystal biosensors,” IEEE Sens. J. 6, 1551-1556 (2006). [CrossRef]
  13. C. J. Choi and B. T. Cunningham, “A 96-well microplate incorporating a replica molded microfluidic network integrated with photonic crystal biosensors for high throughput kinetic biomolecular interaction analysis,” Lab Chip 7, 550-556(2007). [CrossRef] [PubMed]
  14. L. Chan, S. Gosangari, K. Watkin, and B. T. Cunningham, “A label-free photonic crystal biosensor imaging method for detection of cancer cell cytotoxicity and proliferation,” Apoptosis 12, 1061-1068 (2007). [CrossRef] [PubMed]
  15. L. L. Chan, S. Gosangari, K. L. Watkin, and B. T. Cunningham, “Label-free imaging of cancer cells using photonic crystal biosensors and application to cytotoxicity screening of a natural compound library,” Sens. Actuators B 132, 418-425 (2008). [CrossRef]
  16. S. Fan and J. D. Joannopoulos, “Analysis of guided resonances in photonic crystal slabs,” Phys. Rev. B 65, 235112 (2002). [CrossRef]
  17. J. Verdeyen, Laser Electronics (Prentice-Hall, 1995).
  18. Y. Ding and R. Magnusson, “Resonant leaky-mode spectral-band engineering and device applications,” Opt. Express 12, 5661-5674 (2004). [CrossRef] [PubMed]
  19. I. D. Block, P. C. Mathias, N. Ganesh, S. Jones, B. R. Dorvel, V. Chaudhery, L. Vodkin, R. Bashir, and B. T. Cunningham, “A detection instrument for enhanced-fluorescence and label-free imaging on photonic crystal surfaces,” Opt. Express 17, 13222-13235 (2009). [CrossRef] [PubMed]
  20. B. T. Cunningham, B. Lin, J. Qiu, P. Li, J. Pepper, and B. Hugh, “A plastic colorimetric resonant optical biosensor for multiparallel detection of label-free biochemical interactions,” Sens. Actuators B 85, 219-226 (2002). [CrossRef]
  21. I. D. Block, N. Ganesh, M. Lu, and B. T. Cunningham, “A sensitivity model for predicting photonic crystal biosensor performance,” IEEE Sens. J. 8, 274-280 (2008). [CrossRef]
  22. W. C. Karl and H. H. Pien, “High-resolution biosensor spectral peak shift estimation,” IEEE Trans. Signal Process. 53, 4631-4639 (2005). [CrossRef]
  23. R. Auburn, D. P. Kreil, L. A. Meadows, B. Fischer, S. S. Matilla, and S. Russell, “Robotic spotting of cDNA arrays and oligonucleotide microarrays,” Trends Biotechnol. 23, 374-379 (2005). [CrossRef] [PubMed]
  24. A. W. Peterson, R. J. Heaton, and R. M. Georgiadis, “The effect of surface probe density on DNA hybridization,” Nucleic Acids Res. 29, 5163-5168 (2001). [CrossRef]
  25. D. S. Dandy, P. Wu, and D. W. Grainger, “Array feature size influences nucleic acid surface capture in DNA microarrays,” Proc. Natl. Acad. Sci. USA 104, 8223-8228 (2007). [CrossRef] [PubMed]

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