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Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics

| EXPLORING THE INTERFACE OF LIGHT AND BIOMEDICINE

  • Editors: Andrew Dunn and Anthony Durkin
  • Vol. 5, Iss. 14 — Nov. 16, 2010

Minimally invasive assessment of the effect of mannitol and hypertonic saline therapy on traumatic brain edema using measurements of reduced scattering coefficient ( μ s )

Jieru Xie, Zhiyu Qian, Tianming Yang, Weitao Li, and Guangxia Hu  »View Author Affiliations


Applied Optics, Vol. 49, Issue 28, pp. 5407-5414 (2010)
http://dx.doi.org/10.1364/AO.49.005407


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Abstract

Minimally invasive functional near infrared spectroscopy (fNIRs) technology was utilized to assess the effects of mannitol and hypertonic saline (HS) in treating traumatic brain edema (TBE). Rats with TBE models were given mannitol or HS in different dosages for different groups. The reduced scattering coefficient ( μ s ) of the local cortex of rats was simultaneously monitored and recorded in vivo and real time by the minimally invasive fNIRs system. Brain water content (BWC) was measured by the wet and dry weight method at 1, 6, 24, 72, and 120 h after injury and treatment. Effects of treating TBE with different dehydration agents were then assessed by recording μ s and BWC before and after administration of dehydration. In this study, the dynamic changes of brain edema and the effects of dehydration therapy were continuously monitored. Results implied that μ s of the local cortex in rats is a good indicator for assessing effects of treatment of TBE. By recording changes in the value of μ s , the following conclusions were obtained: HS is more effective than mannitol in reducing cerebral edema. The effect of dehydration of HS is only related to osmotic gradient and has no correlation with concentration.

© 2010 Optical Society of America

OCIS Codes
(170.1470) Medical optics and biotechnology : Blood or tissue constituent monitoring
(170.6510) Medical optics and biotechnology : Spectroscopy, tissue diagnostics
(170.6930) Medical optics and biotechnology : Tissue
(280.1415) Remote sensing and sensors : Biological sensing and sensors

ToC Category:
Medical Optics and Biotechnology

History
Original Manuscript: December 11, 2009
Revised Manuscript: May 9, 2010
Manuscript Accepted: August 6, 2010
Published: September 28, 2010

Virtual Issues
Vol. 5, Iss. 14 Virtual Journal for Biomedical Optics

Citation
Jieru Xie, Zhiyu Qian, Tianming Yang, Weitao Li, and Guangxia Hu, "Minimally invasive assessment of the effect of mannitol and hypertonic saline therapy on traumatic brain edema using measurements of reduced scattering coefficient (μs′)," Appl. Opt. 49, 5407-5414 (2010)
http://www.opticsinfobase.org/vjbo/abstract.cfm?URI=ao-49-28-5407

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