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Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics


  • Editors: Andrew Dunn and Anthony Durkin
  • Vol. 6, Iss. 1 — Jan. 3, 2011

Multispectral quantitative photoacoustic imaging of osteoarthritis in finger joints

Jiaying Xiao and Jishan He  »View Author Affiliations

Applied Optics, Vol. 49, Issue 30, pp. 5721-5727 (2010)

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We present in vivo experimental evidence that multispectral quantitative photoacoustic tomography (qPAT) has the potential to detect osteoarthritis (OA) in the finger joints. In this pilot study, two OA patients and three healthy volunteers were enrolled, and their distal interphalangeal (DIP) joints were examined photoacoustically by a multispectral PAT scanner. Images of tissue physiological/functional parameters including oxyhemoglobin, deoxyhemoglobin, oxygen saturation, and water content, along with the tissue acoustic velocity of all the examined joints, were simultaneously recovered using a finite element reconstruction algorithm for multispectral photoacoustic measurements. The recovered multispectral photoacoustic images show that the OA joints have significantly elevated water content, decreased oxygen saturation, and increased acoustic velocity compared to the normal joints.

© 2010 Optical Society of America

OCIS Codes
(110.5120) Imaging systems : Photoacoustic imaging
(170.1610) Medical optics and biotechnology : Clinical applications
(170.3010) Medical optics and biotechnology : Image reconstruction techniques

ToC Category:
Medical Optics and Biotechnology

Original Manuscript: July 2, 2010
Manuscript Accepted: August 16, 2010
Published: October 12, 2010

Virtual Issues
Vol. 6, Iss. 1 Virtual Journal for Biomedical Optics

Jiaying Xiao and Jishan He, "Multispectral quantitative photoacoustic imaging of osteoarthritis in finger joints," Appl. Opt. 49, 5721-5727 (2010)

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