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Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics

| EXPLORING THE INTERFACE OF LIGHT AND BIOMEDICINE

  • Editors: Andrew Dunn and Anthony Durkin
  • Vol. 6, Iss. 1 — Jan. 3, 2011

Measurement of the optical properties of a two-layer model of the human head using broadband near-infrared spectroscopy

Olivia Pucci, Vladislav Toronov, and Keith St. Lawrence  »View Author Affiliations


Applied Optics, Vol. 49, Issue 32, pp. 6324-6332 (2010)
http://dx.doi.org/10.1364/AO.49.006324


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Abstract

We present the development of a continuous-wave method of quantifying the optical properties of a two-layered model of the human head using a broadband spectral approach. Absolute absorption and scattering properties of the upper and lower layers of phantoms with known optical properties were reconstructed from steady-state multi-distance measurements by performing differential fit analysis of the near-infrared reflectance spectrum between 700 and 1000 nm . From spectra acquired at 10, 20, and 30 mm , the concentration of a chromophore in the bottom layer was determined within an error of 10% in the presence of a 15 mm thick top layer. These results demonstrate that our method was able to determine the optical properties of the lower layer, which represents brain, with acceptable error at specific source–detector distances.

© 2010 Optical Society of America

OCIS Codes
(120.6200) Instrumentation, measurement, and metrology : Spectrometers and spectroscopic instrumentation
(170.6510) Medical optics and biotechnology : Spectroscopy, tissue diagnostics

ToC Category:
Instrumentation, Measurement, and Metrology

History
Original Manuscript: March 8, 2010
Revised Manuscript: September 28, 2010
Manuscript Accepted: October 7, 2010
Published: November 9, 2010

Virtual Issues
Vol. 6, Iss. 1 Virtual Journal for Biomedical Optics

Citation
Olivia Pucci, Vladislav Toronov, and Keith St. Lawrence, "Measurement of the optical properties of a two-layer model of the human head using broadband near-infrared spectroscopy," Appl. Opt. 49, 6324-6332 (2010)
http://www.opticsinfobase.org/vjbo/abstract.cfm?URI=ao-49-32-6324

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