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Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics

| EXPLORING THE INTERFACE OF LIGHT AND BIOMEDICINE

  • Editors: Andrew Dunn and Anthony Durkin
  • Vol. 7, Iss. 8 — Aug. 2, 2012

Fast multispectral diffuse optical tomography system for in vivo three-dimensional imaging of seizure dynamics

Jianjun Yang, Tao Zhang, Hao Yang, and Huabei Jiang  »View Author Affiliations


Applied Optics, Vol. 51, Issue 16, pp. 3461-3469 (2012)
http://dx.doi.org/10.1364/AO.51.003461


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Abstract

We describe a multispectral continuous-wave diffuse optical tomography (DOT) system that can be used for in vivo three-dimensional (3-D) imaging of seizure dynamics. Fast 3-D data acquisition is realized through a time multiplexing approach based on a parallel lighting configuration—our system can achieve 0.12 ms per source per wavelength and up to a 14 Hz sampling rate for a full set of data for 3-D DOT image reconstruction. The system is validated using both static and dynamic tissue-like phantoms. An initial in vivo experiment using a rat model of seizure is also demonstrated.

© 2012 Optical Society of America

OCIS Codes
(110.0110) Imaging systems : Imaging systems
(110.3080) Imaging systems : Infrared imaging
(110.6960) Imaging systems : Tomography

ToC Category:
Imaging Systems

History
Original Manuscript: January 13, 2012
Revised Manuscript: March 9, 2012
Manuscript Accepted: March 9, 2012
Published: May 31, 2012

Virtual Issues
Vol. 7, Iss. 8 Virtual Journal for Biomedical Optics

Citation
Jianjun Yang, Tao Zhang, Hao Yang, and Huabei Jiang, "Fast multispectral diffuse optical tomography system for in vivo three-dimensional imaging of seizure dynamics," Appl. Opt. 51, 3461-3469 (2012)
http://www.opticsinfobase.org/vjbo/abstract.cfm?URI=ao-51-16-3461

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