Optoacoustic imaging represents a new modality that allows noninvasive in vivo molecular imaging with optical contrast and acoustical resolution. Whereas structural or functional imaging applications such as imaging of vasculature do not require contrast enhancing agents, nanoprobes with defined biochemical binding behavior are needed for molecular imaging tasks. Since the contrast of this modality is based on the local optical absorption coefficient, all particle or molecule types that show significant absorption cross sections in the spectral range of the laser wavelength used for signal generation are suitable contrast agents. Currently, several particle types such as gold nanospheres, nanoshells, nanorods, or polymer particles are used as optoacoustic contrast agents. These particles have specific advantages with respect to their absorption properties, or in terms of biologically relevant features (biodegradability, binding to molecular markers). In the present study, a comparative analysis of the signal generation efficiency of gold nanorods, polymeric particles, and magnetite particles using a 1064 nm Nd:YAG laser for signal generation is described.
© 2012 Optical Society of America
Original Manuscript: August 24, 2012
Revised Manuscript: October 22, 2012
Manuscript Accepted: October 23, 2012
Published: November 20, 2012
Vol. 7, Iss. 12 Virtual Journal for Biomedical Optics
Wolfgang Bost, Robert Lemor, and Marc Fournelle, "Comparison of the optoacoustic signal generation efficiency of different nanoparticular contrast agents," Appl. Opt. 51, 8041-8046 (2012)