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Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics

| EXPLORING THE INTERFACE OF LIGHT AND BIOMEDICINE

  • Editor: Gregory W. Faris
  • Vol. 3, Iss. 4 — Apr. 23, 2008

Fiber-Optic Infrared Reflection Absorption Spectroscopy for Trace Analysis on Surfaces of Varying Roughness. Part II: Acetaminophen on Stainless Steel

Benjamin B. Perston, Michelle L. Hamilton, Peter W. Harland, Mary A. Thomson, Peter J. Melling, and Bryce E. Williamson

Applied Spectroscopy, Vol. 62, Issue 3, pp. 312-318 (2008)


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Abstract

Investigations of the effects of surface roughness on the utility of grazing-angle Fourier transform infrared reflection absorption spectroscopy (IRRAS) as a method for quantifying trace contamination of metal surfaces have been extended to acetaminophen, a model active pharmaceutical agent, on 316 stainless steel. The effects are more complicated than for the surfactant sodium dodecyl sulfate (SDS) on stainless steel; they include a strong surface-finish dependence of sensitivity and nonlinear behavior at surface loadings above ∼1–2 μg cm−2. Using data from samples in the loading range 0–0.5 μg cm−2, unbiased partial least squared calibrations can be readily achieved for individual surface finishes with detection limits of LD ≈ 0.15 μg cm−2. However, as found for SDS on stainless steel, models built using data from samples of mixed surface roughness are more problematic.

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Vol. 3, Iss. 4 Virtual Journal for Biomedical Optics

Citation
Benjamin B. Perston, Michelle L. Hamilton, Peter W. Harland, Mary A. Thomson, Peter J. Melling, and Bryce E. Williamson, "Fiber-Optic Infrared Reflection Absorption Spectroscopy for Trace Analysis on Surfaces of Varying Roughness. Part II: Acetaminophen on Stainless Steel," Appl. Spectrosc. 62, 312-318 (2008)
http://www.opticsinfobase.org/vjbo/abstract.cfm?URI=as-62-3-312


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