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Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics

| EXPLORING THE INTERFACE OF LIGHT AND BIOMEDICINE

  • Editors: Andrew Dunn and Anthony Durkin
  • Vol. 5, Iss. 14 — Nov. 16, 2010

Hydrogel Network Formation Revised: High-Resolution Magic Angle Spinning Nuclear Magnetic Resonance as a Powerful Tool for Measuring Absolute Hydrogel Cross-Link Efficiencies

Sandra Van Vlierberghe, Bernd Fritzinger, José C. Martins, and Peter Dubruel

Applied Spectroscopy, Vol. 64, Issue 10, pp. 1176-1180 (2010)


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Abstract

In the present work, high-resolution magic angle spinning (hr-MAS) NMR spectroscopy is applied as a straightforward nondestructive technique to quantify unreacted methacrylamide functionalities in cross-linked gelatin hydrogels. By adjusting several cross-linking parameters including the ultraviolet (UV) irradiation time and the photo-initiator concentration, the cross-linking degree can be easily varied. Remarkably, under all experimental conditions typically applied for hydrogel development, no more than 40% of the methacrylamide moieties present have reacted. The hr-MAS based approach to determine the cross-linking efficiency is shown to provide an innovative and more convenient alternative to the well-established classical techniques. In addition, the results obtained are in good correlation with mechanical analysis data.

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Vol. 5, Iss. 14 Virtual Journal for Biomedical Optics

Citation
Sandra Van Vlierberghe, Bernd Fritzinger, José C. Martins, and Peter Dubruel, "Hydrogel Network Formation Revised: High-Resolution Magic Angle Spinning Nuclear Magnetic Resonance as a Powerful Tool for Measuring Absolute Hydrogel Cross-Link Efficiencies," Appl. Spectrosc. 64, 1176-1180 (2010)
http://www.opticsinfobase.org/vjbo/abstract.cfm?URI=as-64-10-1176

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