OSA's Digital Library

Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics

| EXPLORING THE INTERFACE OF LIGHT AND BIOMEDICINE

  • Editors: Andrew Dunn and Anthony Durkin
  • Vol. 7, Iss. 9 — Aug. 28, 2012

Determination of Optical Coefficients and Fractal Dimensional Parameters of Cancerous and Normal Prostate Tissues

Yang Pu, Wubao Wang, Mohammad AL-Rubaiee, Swapan Kumar Gayen, and Min Xu

Applied Spectroscopy, Vol. 66, Issue 7, pp. 828-834 (2012)


View Full Text Article

Acrobat PDF (713 KB)





Browse Journals / Lookup Meetings

Browse by Journal and Year


   


Lookup Conference Papers

Close Browse Journals / Lookup Meetings

Article Tools

Share
Citations
  • Export Citation/Save Click for help

Abstract

Optical extinction and diffuse reflection spectra of cancerous and normal prostate tissues in the 750 to 860 nm spectral range were measured. Optical extinction measurements using thin <i>ex vivo</i> prostate tissue samples were used to determine the scattering coefficient (μ<sub>s</sub>), while diffuse reflection measurements using thick prostate tissue samples were used to extract the absorption coefficient (μ<sub>a</sub>) and the reduced scattering coefficient (μ's ). The anisotropy factor (<i>g</i>) was obtained using the extracted values of μ<sub>s</sub> and μ's. The values of fractal dimension (<i>D</i><sub>f</sub>) of cancerous and normal prostate tissues were obtained by fitting to the wavelength dependence of μ's. The number of scattering particles contributing to μ<sub>s</sub> as a function of particle size and the cutoff diameter <i>D</i><sub>max</sub> as a function of <i>g</i> were investigated using the fractal soft tissue model and Mie theory. Results show that <i>D</i><sub>max</sub> of the normal tissue is larger than that of the cancerous tissue. The cutoff diameter <i>D</i><sub>max</sub> is observed to agree with the nuclear size for the normal tissues and the nucleolar size for the cancerous tissues. Transmission spectral polarization imaging measurements were performed that could distinguish the cancerous prostate tissue samples from the normal tissue samples based on the differences between their absorption and scattering parameters.

Virtual Issues
Vol. 7, Iss. 9 Virtual Journal for Biomedical Optics

Citation
Yang Pu, Wubao Wang, Mohammad AL-Rubaiee, Swapan Kumar Gayen, and Min Xu, "Determination of Optical Coefficients and Fractal Dimensional Parameters of Cancerous and Normal Prostate Tissues," Appl. Spectrosc. 66, 828-834 (2012)
http://www.opticsinfobase.org/vjbo/abstract.cfm?URI=as-66-7-828

You do not have subscription access to this journal. Citation lists with outbound citation links are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Log in to access OSA Member Subscription

You do not have subscription access to this journal. Cited by links are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Log in to access OSA Member Subscription

« Previous Article  |  Next Article »

OSA is a member of CrossRef.

CrossCheck Deposited