Abstract
A flexible fiber probe for surface-enhanced Raman scattering (SERS) measurement was developed for performing an extremely sensitive Raman analysis for biomedical applications. The Raman probe consists of a ball lens mounted on a hollow optical fiber and allows Raman signals to be measured by a contact mode. Gold (Au) nanoparticles were placed on the ball lens by a dip-and-dry method. The increase in the background noise due to the deposition of the Au nanocolloids was very small. By using this new SERS probe, a Raman spectrum of 5% gelatin aqueous solution was successfully measured. A strong SERS signal was observed for the gelatin molecule in the solution. In particular, a C-S stretching band at 732 cm <sup>−1</sup> due to methionine residues, which could not be observed by an ordinary Raman microscope system, was observed clearly. The content of methionine was less than 1% in the gelatin molecule. The results show that this SERS probe has very high sensitivity and holds considerable promise in the applications of SERS spectroscopy for direct diagnosis of cancer tissues.
PDF Article
More Like This
Cited By
You do not have subscription access to this journal. Cited by links are available to subscribers only. You may subscribe either as an Optica member, or as an authorized user of your institution.
Contact your librarian or system administrator
or
Login to access Optica Member Subscription