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Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics

| EXPLORING THE INTERFACE OF LIGHT AND BIOMEDICINE

  • Editors: Andrew Dunn and Anthony Durkin
  • Vol. 7, Iss. 11 — Oct. 31, 2012

Development of a Flexible Fiber Surface-Enhanced Raman Scattering (SERS) Probe Using a Hollow Optical Fiber and Gold Nanoparticles

Toshiaki Suzuki, Yasutaka Kitahama, Yuji Matsuura, Yukihiro Ozaki, and Hidetoshi Sato

Applied Spectroscopy, Vol. 66, Issue 9, pp. 1022-1026 (2012)


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Abstract

A flexible fiber probe for surface-enhanced Raman scattering (SERS) measurement was developed for performing an extremely sensitive Raman analysis for biomedical applications. The Raman probe consists of a ball lens mounted on a hollow optical fiber and allows Raman signals to be measured by a contact mode. Gold (Au) nanoparticles were placed on the ball lens by a dip-and-dry method. The increase in the background noise due to the deposition of the Au nanocolloids was very small. By using this new SERS probe, a Raman spectrum of 5% gelatin aqueous solution was successfully measured. A strong SERS signal was observed for the gelatin molecule in the solution. In particular, a C-S stretching band at 732 cm −1 due to methionine residues, which could not be observed by an ordinary Raman microscope system, was observed clearly. The content of methionine was less than 1% in the gelatin molecule. The results show that this SERS probe has very high sensitivity and holds considerable promise in the applications of SERS spectroscopy for direct diagnosis of cancer tissues.

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Vol. 7, Iss. 11 Virtual Journal for Biomedical Optics

Citation
Toshiaki Suzuki, Yasutaka Kitahama, Yuji Matsuura, Yukihiro Ozaki, and Hidetoshi Sato, "Development of a Flexible Fiber Surface-Enhanced Raman Scattering (SERS) Probe Using a Hollow Optical Fiber and Gold Nanoparticles," Appl. Spectrosc. 66, 1022-1026 (2012)
http://www.opticsinfobase.org/vjbo/abstract.cfm?URI=as-66-9-1022


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