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Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics


  • Editor: Gregory W. Faris
  • Vol. 2, Iss. 3 — Mar. 7, 2007

Numerical study on the validity of the diffusion approximation for computational optical biopsy

Haiou Shen, WenXiang Cong, Xin Qian, Kumar Durairaj, and Ge Wang  »View Author Affiliations

JOSA A, Vol. 24, Issue 2, pp. 423-429 (2007)

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Currently, we are developing a computational optical biopsy technology for molecular sensing. We use the diffusion equation to model photon propagation but have a concern about the accuracy of diffusion approximation when the optical sensor is close to a bioluminescent source. We derive formulas to describe photon fluence for point and ball sources and measurement formulas for an idealized optical biopsy probe. Then, we numerically compare the diffusion approximation and the radiative transport as implemented by Monte Carlo simulation in the cases of point and ball sources. Our simulation results show that the diffusion approximation can be accurately applied if μ s μ a even if the sensor is very close to the source ( > 1 mm ) . Furthermore, an approximate formula is given to describe the measurement of a cut-end fiber probe for a ball source.

© 2007 Optical Society of America

OCIS Codes
(170.3660) Medical optics and biotechnology : Light propagation in tissues
(170.6280) Medical optics and biotechnology : Spectroscopy, fluorescence and luminescence
(290.1990) Scattering : Diffusion

ToC Category:
Medical Optics and Biotechnology

Original Manuscript: April 5, 2006
Revised Manuscript: August 23, 2006
Manuscript Accepted: August 24, 2006

Virtual Issues
Vol. 2, Iss. 3 Virtual Journal for Biomedical Optics

Haiou Shen, WenXiang Cong, Xin Qian, Kumar Durairaj, and Ge Wang, "Numerical study on the validity of the diffusion approximation for computational optical biopsy," J. Opt. Soc. Am. A 24, 423-429 (2007)

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