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Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics

| EXPLORING THE INTERFACE OF LIGHT AND BIOMEDICINE

  • Editors: Andrew Dunn and Anthony Durkin
  • Vol. 6, Iss. 1 — Jan. 3, 2011

Adaptive optics scanning laser ophthalmoscope with integrated wide-field retinal imaging and tracking

R. Daniel Ferguson, Zhangyi Zhong, Daniel X. Hammer, Mircea Mujat, Ankit H. Patel, Cong Deng, Weiyao Zou, and Stephen A. Burns  »View Author Affiliations


JOSA A, Vol. 27, Issue 11, pp. A265-A277 (2010)
http://dx.doi.org/10.1364/JOSAA.27.00A265


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Abstract

We have developed a new, unified implementation of the adaptive optics scanning laser ophthalmoscope (AOSLO) incorporating a wide-field line-scanning ophthalmoscope (LSO) and a closed-loop optical retinal tracker. AOSLO raster scans are deflected by the integrated tracking mirrors so that direct AOSLO stabilization is automatic during tracking. The wide-field imager and large-spherical-mirror optical interface design, as well as a large-stroke deformable mirror (DM), enable the AOSLO image field to be corrected at any retinal coordinates of interest in a field of > 25 deg . AO performance was assessed by imaging individuals with a range of refractive errors. In most subjects, image contrast was measurable at spatial frequencies close to the diffraction limit. Closed-loop optical (hardware) tracking performance was assessed by comparing sequential image series with and without stabilization. Though usually better than 10 μ m rms, or 0.03 deg , tracking does not yet stabilize to single cone precision but significantly improves average image quality and increases the number of frames that can be successfully aligned by software-based post-processing methods. The new optical interface allows the high-resolution imaging field to be placed anywhere within the wide field without requiring the subject to re-fixate, enabling easier retinal navigation and faster, more efficient AOSLO montage capture and stitching.

© 2010 Optical Society of America

OCIS Codes
(170.4460) Medical optics and biotechnology : Ophthalmic optics and devices
(170.5755) Medical optics and biotechnology : Retina scanning
(110.1080) Imaging systems : Active or adaptive optics

History
Original Manuscript: April 26, 2010
Revised Manuscript: August 16, 2010
Manuscript Accepted: August 17, 2010
Published: October 18, 2010

Virtual Issues
Vol. 6, Iss. 1 Virtual Journal for Biomedical Optics

Citation
R. Daniel Ferguson, Zhangyi Zhong, Daniel X. Hammer, Mircea Mujat, Ankit H. Patel, Cong Deng, Weiyao Zou, and Stephen A. Burns, "Adaptive optics scanning laser ophthalmoscope with integrated wide-field retinal imaging and tracking," J. Opt. Soc. Am. A 27, A265-A277 (2010)
http://www.opticsinfobase.org/vjbo/abstract.cfm?URI=josaa-27-11-A265

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