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Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics


  • Editor: Gregory W. Faris
  • Vol. 5, Iss. 10 — Jul. 19, 2010

Spectrally resolved three-dimensional bioluminescence tomography with a level-set strategy

Kai Liu, Xin Yang, Dan Liu, Chenghu Qin, Junting Liu, Zhijun Chang, Min Xu, and Jie Tian  »View Author Affiliations

JOSA A, Vol. 27, Issue 6, pp. 1413-1423 (2010)

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A reconstruction method is presented for spectrally resolved three-dimensional bioluminescence tomography (BLT) in heterogeneous media using a level-set strategy. In order to reconstruct internal bioluminescent sources, a level-set strategy is utilized to quantitatively localize the distribution of bioluminescent sources. The results in numerical phantom experiments clearly show that the proposed method can tolerate different initial values and noise levels and, furthermore, can work credibly even when the number of phases (levels) is not known a priori. In addition, a mouse atlas reconstruction is employed to demonstrate the effectiveness of the proposed method in turbid mouse geometry. Finally, the physical experiment further evaluates the method’s potential in practical applications.

© 2010 Optical Society of America

OCIS Codes
(100.3190) Image processing : Inverse problems
(170.3660) Medical optics and biotechnology : Light propagation in tissues
(170.6280) Medical optics and biotechnology : Spectroscopy, fluorescence and luminescence
(170.6960) Medical optics and biotechnology : Tomography

ToC Category:
Medical Optics and Biotechnology

Original Manuscript: August 20, 2009
Revised Manuscript: March 15, 2010
Manuscript Accepted: April 6, 2010
Published: May 21, 2010

Virtual Issues
Vol. 5, Iss. 10 Virtual Journal for Biomedical Optics

Kai Liu, Xin Yang, Dan Liu, Chenghu Qin, Junting Liu, Zhijun Chang, Min Xu, and Jie Tian, "Spectrally resolved three-dimensional bioluminescence tomography with a level-set strategy," J. Opt. Soc. Am. A 27, 1413-1423 (2010)

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