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Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics

| EXPLORING THE INTERFACE OF LIGHT AND BIOMEDICINE

  • Editor: Gregory W. Faris
  • Vol. 1, Iss. 5 — May. 5, 2006

Adaptive optics enhanced simultaneous en-face optical coherence tomography and scanning laser ophthalmoscopy

David Merino, Chris Dainty, Adrian Bradu, and Adrian Gh. Podoleanu  »View Author Affiliations


Optics Express, Vol. 14, Issue 8, pp. 3345-3353 (2006)
http://dx.doi.org/10.1364/OE.14.003345


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Abstract

A novel combination of adaptive optics with a simultaneous en-face OCT/SLO system for high resolution imaging of the in-vivo human retina is presented. Pairs of retinal images are shown and performance of the system is evaluated with and without dynamic wavefront correction. The adaptive optics closed loop system operates at a frame rate of 9 Hz and incorporates a Shack-Hartmann wavefront sensor based on a highly sensitive Andor camera and a 37 actuator OKO membrane deformable mirror to correct for ocular aberrations. The system produces C-scan pairs of images at a frame rate of 2 Hz. The correction of aberrations produced by the adaptive optics closed-loop system increased the signal-to-noise ratio in images obtained from volunteer eyes by up to 6 dB in the OCT channel and up to 9 dB in the SLO channel. A slight improvement in the lateral resolution was also obtained, from 6.5 μm before to 5 μm after closing the adaptive optics loop.

© 2006 Optical Society of America

OCIS Codes
(010.1080) Atmospheric and oceanic optics : Active or adaptive optics
(170.4460) Medical optics and biotechnology : Ophthalmic optics and devices
(170.4500) Medical optics and biotechnology : Optical coherence tomography

ToC Category:
Medical Optics and Biotechnology

History
Original Manuscript: February 9, 2006
Revised Manuscript: April 7, 2006
Manuscript Accepted: April 7, 2006
Published: April 17, 2006

Virtual Issues
Vol. 1, Iss. 5 Virtual Journal for Biomedical Optics

Citation
David Merino, Chris Dainty, Adrian Bradu, and Adrian Gh. Podoleanu, "Adaptive optics enhanced simultaneous en-face optical coherence tomography and scanning laser ophthalmoscopy," Opt. Express 14, 3345-3353 (2006)
http://www.opticsinfobase.org/vjbo/abstract.cfm?URI=oe-14-8-3345


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References

  1. P.L. Kaufman, A. Alm, "Adler’s Physiology of the Eye," Mosby (2003)
  2. R. H. Webb, G. W. Hughes, O. Pomerantzeff "Flying spot TV ophthalmoscope," Appl. Opt. 19,2991-2997 (1980) [CrossRef] [PubMed]
  3. R. H. Webb, G.W. Hughes, F. C. Delori, "Confocal scanning laser ophthalmoscope," Appl. Opt. 26,1492 (1987) [CrossRef] [PubMed]
  4. W. J. DonnellyIII, A. Roorda, "Optimal pupil size in the human eye for axial resolution," J. Opt. Soc. Am. A 20,2010-2015 (2003) [CrossRef]
  5. S. Marcos, S. A. Burns, P. M. Prieto, R. Navarro, B. Baraibar "Investigating sources of variablity of monochromatic and transverse chromatic aberrations across the eye," Vision Res. 41,3861-3871 (2001) [CrossRef] [PubMed]
  6. H. Hofer, P. Artal, B. Singer, J. L. Arag´on, D. R. Williams, "Dynamics of the eye’s aberration," J. Opt. Soc. Am. A 18,497-506 (2001) [CrossRef]
  7. J. Liang, D. R. Williams, D. T. Miller, "Supernormal vision and high-resolution retinal imaging through adaptive optics," J. Opt. Soc. Am. A 14,2884-2892 (1997) [CrossRef]
  8. J. Carroll, M. Neitz, H. Hofer, J. Neitz, D. R. Williams, "Functional photoreceptor loss revealed with adaptive optics: An alternate cause of color blindness," PNAS 101,8461-8466 (2004) [CrossRef] [PubMed]
  9. A. Roorda, F. Romero-Borja, W. J. DonellyIII, H. Queener, T. J. Herbert, M. C. W. Campbell, "Adaptive optics scanning laser ophthalmoscope," Opt. Express 10,405-412 (2002), http://www.opticsinfobase.org/abstract.cfm?URI=oe-10-9-405. [PubMed]
  10. D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W.G. Stinson, W. Chang, M. R. Hee, T. Flotte. K. Gregory, C. A. Puliafito and J. G Fujimoto "Optical coherence tomography,"Science 254,1178-1181 (1991). [CrossRef] [PubMed]
  11. S. A. Al-Chalabi, B. Culshaw and D. E. N. Davies, "Partially coherent sources in interferometric sensors," First International Conference on Optical Fibre Sensors, (1983)
  12. R. C. Youngquist, S. Carr and D. E. N. Davies, "Optical coherence-domain reflectometry: A new optical evaluation technique," Opt. Lett. 12,158-160 (1987) [CrossRef] [PubMed]
  13. M. Mujat, R. Chan, B. Cense, B. Park, C. Joo, T. Akkin, T. Chen, J. de Boer, "Retinal nerve fiber layer thickness map determined from optical coherence tomography images," Opt. Express 13,9480-9491 (2005), http://www.opticsinfobase.org/abstract.cfm?URI=oe-13-23-9480. [CrossRef] [PubMed]
  14. B. Hermann, E. J. Fern´andez, A. Unterhuber, H. Sattmann, A. F. Fercher, W. Drexler "Adaptive-optics ultrahighresolution optical coherence tomography," Opt. Lett. 29, 2142-2144 (2004) [CrossRef] [PubMed]
  15. Y. Zhang, J. Rha, R. S. Jonnal, D. T. Miller "Adaptive optics parallel spectral domain optical coherence tomography for imaging the living retina," Opt. Express 13, 4792-4811 (2005), http://www.opticsinfobase.org/abstract.cfm?URI=oe-13-12-4792. [CrossRef] [PubMed]
  16. R. Zawadzki, S. Jones, S. Olivier, M. Zhao, B. Bower, J. Izatt, S. Choi, S. Laut, and J. Werner, "Adaptive-optics optical coherence tomography for high-resolution and high-speed 3D retinal in vivo imaging," Opt. Express.  13, 8532-8546 (2005), http://www.opticsinfobase.org/abstract.cfm?URI=oe-13-21-8532. [CrossRef] [PubMed]
  17. A. Gh. Podoleanu, G. M. Dobre, D. J. Webb, D. A. Jackson, "Coherence imaging by use of a Newton rings sampling function," Opt. Lett. 21,1789-1971 (1996) [CrossRef] [PubMed]
  18. A. Gh. Podoleanu, G. M. Dobre, D. A. Jackson, "En-face coherence imaging using galvanometer scanner modulation," Opt. Lett. 23,147-149 (1998) [CrossRef]
  19. A. Gh.Podoleanu, J. A. Rogers, D. A. Jackson, "OCT en-face images from the retina with adjustable depth resolution in real time," IEEE J. Sel. Top. in Quantum Electron., 5, 1176-1184 (1999). [CrossRef]
  20. A. Gh. Podoleanu, D. A. Jackson, "Combined Optical Coherence Tomograph and Scanning Laser Ophthalmoscope," Electron. Lett. 34, 1088-1090 (1998) [CrossRef]
  21. A. Gh.Podoleanu, G. M.Dobre, R. G. Cucu, R. Rosen, P. Garcia, J. Nieto, D. Will, R. Gentile, T. Muldoon, J. Walsh, L. A. Yannuzzi, Y. Fisher, D. Orlock, RWeitz, J. A. Rogers, S. Dunne, A. Boxer, "Combined Multiplanar Optical Coherence Tomography and Confocal Scanning Ophthalmoscopy," J. Biomed. Opt. 9,86-93 (2004). [CrossRef] [PubMed]
  22. A. Gh. Podoleanu, D. A. Jackson, "Noise Analysis of a Combined Optical Coherence Tomograph and a Confocal Scanning Ophthalmoscope," Appl. Opt. 38,2116 - 2127 (1999) [CrossRef]
  23. The European Committee for Electrotechnical Standardization,"Safety of Laser Products" (2003)
  24. A. Gh. Podoleanu, M. Seeger, G. M. Dobre, D. J. Webb, D. A. Jackson, "Transversal and longitudinal images from the retina of the living eye using low-coherence reflectometry," J. Biomed. Opt. 3, 12-20 (1998) [CrossRef]
  25. F. Roddier, "Adaptive Optics in Astronomy," Cambridge University Press (1999)
  26. E. Dalimier, C. Dainty, "Comparative analysis of deformable mirrors for ocular adaptive optics," Opt. Express 13,4275-4285 (2005), http://www.opticsinfobase.org/abstract.cfm?URI=oe-13-11-4275. [CrossRef] [PubMed]

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