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Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics

| EXPLORING THE INTERFACE OF LIGHT AND BIOMEDICINE

  • Editor: Gregory W. Faris
  • Vol. 1, Iss. 5 — May. 5, 2006

One-laser interferometric broadband coherent anti-Stokes Raman scattering

Tak W. Kee, Hongxia Zhao, and Marcus T. Cicerone  »View Author Affiliations


Optics Express, Vol. 14, Issue 8, pp. 3631-3640 (2006)
http://dx.doi.org/10.1364/OE.14.003631


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Abstract

We introduce an interferometric technique for eliminating the non-resonant background of broadband coherent anti-Stokes Raman scattering (CARS) microscopy. CARS microscopy has been used for imaging a number of biological samples and processes, but the studies are mostly limited to detecting lipids in biological systems by probing the C-H stretch. Non-resonant background and incoherent noise sources can easily overwhelm less intense signals from other molecular vibrations. In this study, we demonstrate a one-laser broadband interferometric technique that separates the spontaneous Raman scattering-related component of the CARS signal from the non-resonant background using liquid benzonitrile as a model system.

© 2006 Optical Society of America

OCIS Codes
(110.0180) Imaging systems : Microscopy
(120.3180) Instrumentation, measurement, and metrology : Interferometry
(190.4370) Nonlinear optics : Nonlinear optics, fibers
(300.6230) Spectroscopy : Spectroscopy, coherent anti-Stokes Raman scattering

ToC Category:
Spectroscopy

History
Original Manuscript: February 17, 2006
Revised Manuscript: March 28, 2006
Manuscript Accepted: March 30, 2006
Published: April 17, 2006

Virtual Issues
Vol. 1, Iss. 5 Virtual Journal for Biomedical Optics

Citation
Tak W. Kee, Hongxia Zhao, and Marcus T. Cicerone, "One-laser interferometric broadband coherent anti-Stokes Raman scattering," Opt. Express 14, 3631-3640 (2006)
http://www.opticsinfobase.org/vjbo/abstract.cfm?URI=oe-14-8-3631


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References

  1. M. D. Duncan, J. Reintjes, and T. J. Manuccia, "Scanning coherent anti-Stokes Raman microscope," Opt. Lett. 7,350-352 (1982). [CrossRef] [PubMed]
  2. J. X. Cheng and X. S. Xie, "Coherent anti-Stokes Raman scattering microscopy: Instrumentation, theory, and applications," J. Phys. Chem. B 108,827-840 (2004). [CrossRef]
  3. A. Zumbusch, G. R. Holtom, and X. S. Xie, "Three-dimensional vibrational imaging by coherent anti-Stokes Raman scattering," Phys. Rev. Lett. 82,4142-4145 (1999). [CrossRef]
  4. M. O. Scully, G. W. Kattawar, R. P. Lucht, T. Opatrny, H. Pilloff, A. Rebane, A. V. Sokolov, and M. S. Zubairy, "FAST CARS: Engineering a laser spectroscopic technique for rapid identification of bacterial spores," PNAS 99, 10994-11001 (2002). [CrossRef] [PubMed]
  5. S. A. Schaertel, A. C. Albrecht, A. Lau, and A. Kummrow, "Interferometric coherent Raman-spectroscopy with incoherent-light - some applications," Appl. Phys. B: Lasers Opt. 59,377-387 (1994). [CrossRef]
  6. J. X. Cheng, Y. K. Jia, G. F. Zheng, and X. S. Xie, "Laser-scanning coherent anti-Stokes Raman scattering microscopy and applications to cell biology," Biophys. J. 83,502-509 (2002). [CrossRef] [PubMed]
  7. H. F. Wang, Y. Fu, P. Zickmund, R. Y. Shi, and J. X. Cheng, "Coherent anti-Stokes Raman scattering imaging of axonal myelin in live spinal tissues," Biophys. J. 89,581-591 (2005). [CrossRef] [PubMed]
  8. E. O. Potma, X. S. Xie, L. Muntean, J. Preusser, D. Jones, J. Ye, S. R. Leone, W. D. Hinsberg, and W. Schade, "Chemical imaging of photoresists with coherent anti-Stokes Raman scattering (CARS) microscopy," J. Phys. Chem. B 108,1296-1301 (2004). [CrossRef]
  9. J. X. Cheng, A. Volkmer, L. D. Book, and X. S. Xie, "Multiplex coherent anti-Stokes Raman scattering microspectroscopy and study of lipid vesicles," J. Phys. Chem. B 106,8493-8498 (2002). [CrossRef]
  10. K. P. Knutsen, J. C. Johnson, A. E. Miller, P. B. Petersen, and R. J. Saykally, "High spectral resolution multiplex CARS spectroscopy using chirped pulses," Chem. Phys. Lett. 387,436-441 (2004). [CrossRef]
  11. M. Muller and J. M. Schins, "Imaging the thermodynamic state of lipid membranes with multiplex CARS microscopy," J. Phys. Chem. B 106,3715-3723 (2002). [CrossRef]
  12. H. Kano and H. Hamaguchi, "Femtosecond coherent anti-Stokes Raman scattering spectroscopy using supercontinuum generated from a photonic crystal fiber," Appl. Phys. Lett. 85,4298-4300 (2004). [CrossRef]
  13. T. W. Kee and M. T. Cicerone, "Simple approach to one-laser, broadband coherent anti-Stokes Raman scattering microscopy," Opt. Lett. 29,2701-2703 (2004). [CrossRef] [PubMed]
  14. G. I. Petrov and V. V. Yakovlev, "Enhancing red-shifted white-light continuum generation in optical fibers for applications in nonlinear Raman microscopy," Opt. Express 13,1299-1306 (2005). [CrossRef] [PubMed]
  15. J. L. Oudar, R. W. Smith, and Y. R. Shen, "Polarization-sensitive coherent anti-Stokes Raman-spectroscopy," Appl. Phys. Lett. 34,758-760 (1979). [CrossRef]
  16. A. Volkmer, L. D. Book, and X. S. Xie, "Time-resolved coherent anti-Stokes Raman scattering microscopy: Imaging based on Raman free induction decay," Appl. Phys. Lett. 80,1505-1507 (2002). [CrossRef]
  17. J. X. Cheng, A. Volkmer, L. D. Book, and X. S. Xie, "An epi-detected coherent anti-Stokes Raman scattering (E-CARS) microscope with high spectral resolution and high sensitivity," J. Phys. Chem. B 105,1277-1280 (2001). [CrossRef]
  18. Y. Yacoby, R. Fitzgibbon, and B. Lax, "Coherent cancellation of background in 4-wave mixing spectroscopy," J. Appl. Phys. 51,3072-3077 (1980). [CrossRef]
  19. C. L. Evans, E. O. Potma, M. Puoris'haag, D. Cote, C. P. Lin, and X. S. Xie, "Chemical imaging of tissue in vivo with video-rate coherent anti-Stokes Raman scattering microscopy," PNAS 102,16807-16812 (2005). [CrossRef] [PubMed]
  20. E. O. Potma, C. L. Evans, and X. S. Xie, "Heterodyne coherent anti-Stokes Raman scattering (CARS) imaging," Opt. Lett. 31,241-243 (2006). [CrossRef] [PubMed]
  21. D. Oron, N. Dudovich, D. Yelin, and Y. Silberberg, "Quantum control of coherent anti-Stokes Raman processes," Phys. Rev. A65, (2002). [CrossRef]
  22. S. H. Lim, A. G. Caster, and S. R. Leone, "Single-pulse phase-control interferometric coherent anti-Stokes Raman scattering spectroscopy," Phys. Rev. A 72, (2005). [CrossRef]
  23. D. L. Marks, C. Vinegoni, J. S. Bredfeldt, and S. A. Boppart, "Interferometric differentiation between resonant coherent anti-Stokes Raman scattering and nonresonant four-wave-mixing processes," Appl. Phys. Lett. 85,5787-5789 (2004). http://www.chemistry.ohio-state.edu/~rmccreer/freqcorr/images/benzo.html. [CrossRef]
  24. Certain equipment, instruments or materials are identified in this paper in order to adequately specify the experimental details. Such identification does not imply recommendation by the National Institute of Standards and Technology nor does it imply the materials are necessarily the best available for the purpose.

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